The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia

Vanishri S. Nayak, Nitesh Kumar, Antony S. D'Souza, Sunil S. Nayak, Sri P. Cheruku, K. Sreedhara Ranganath Pai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Stroke is considered to be one of the most important causes of death worldwide. Global ischemia causes widespread brain injury and infarctions in various regions of the brain. Oxidative stress can be considered an important factor in the development of tissue damage, which is caused because of arterial occlusion with subsequent reperfusion. Kapikacchu or Mucuna pruriens, commonly known as velvet bean, is well known for its aphrodisiac activities. It is also used in the treatment of snakebites, depressive neurosis, and Parkinson's disease. Although this plant has different pharmacological actions, its neuroprotective activity has received minimal attention. Thus, this study was carried out with the aim of evaluating the neuroprotective action of M. pruriens in bilateral carotid artery occlusion-induced global cerebral ischemia in Wistar rats. The carotid arteries of both sides were occluded for 30 min and reperfused to induce global cerebral ischemia. The methanolic plant extract was administered to the study animals for 10 days. The brains of the Wistar rats were isolated by decapitation and observed for histopathological and biochemical changes. Cerebral ischemia resulted in significant neurological damage in the brains of the rats that were not treated by M. pruriens. The group subjected to treatment by the M. pruriens extract showed significant protection against brain damage compared with the negative control group, which indicates the therapeutic potential of this plant in ischemia.

Original languageEnglish
Pages (from-to)1195-1201
Number of pages7
JournalNeuroReport
Volume28
Issue number18
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Mucuna
Ischemia
Brain Ischemia
Brain
Carotid Arteries
Wistar Rats
Aphrodisiacs
Brain Infarction
Decapitation
Snake Bites
Plant Extracts
Depressive Disorder
Brain Injuries
Reperfusion
Parkinson Disease
Cause of Death
Oxidative Stress
Stroke
Pharmacology
Control Groups

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nayak, Vanishri S. ; Kumar, Nitesh ; D'Souza, Antony S. ; Nayak, Sunil S. ; Cheruku, Sri P. ; Pai, K. Sreedhara Ranganath. / The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia. In: NeuroReport. 2017 ; Vol. 28, No. 18. pp. 1195-1201.
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The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia. / Nayak, Vanishri S.; Kumar, Nitesh; D'Souza, Antony S.; Nayak, Sunil S.; Cheruku, Sri P.; Pai, K. Sreedhara Ranganath.

In: NeuroReport, Vol. 28, No. 18, 01.01.2017, p. 1195-1201.

Research output: Contribution to journalArticle

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