The emerging trends of falciparum malaria

A study from a tertiary centre in an endemic area of India

Mary Anne Poovathingal, Shivashankara Kaniyoor Nagiri, Nagaraja

Research output: Contribution to journalArticle

Abstract

Objective: To document the various clinical manifestations, lab parameters, complications and outcomes of Falciparum Malaria. The above data would be correlated with the parasitic index to deduce whether it would be an effective measure of the same. Methods: This was a prospective study among 183 inpatients aged above 18 from Kasturba Hospital, Manipal from May 2009 to January 2011. Ethical clearance was taken. Statistical analysis was done with the independent paired t test, linear correlation and Chi square test using SPSS 16. Results: In this study 78% cases were males. Most cases occurred during the monsoons. Fever was the major presentation with others being jaundice, vomiting and head ache. 50.8 % had complications, including hepatic dysfunction (40.9%), renal failure (19.13%), shock (7%), altered sensorium (9%), ARDS (3.27%) and severe anemia (1.63%). Hypoglycemia and gram negative sepsis were rare. Parasitic index, renal parameters and death were correlating positively. ESR was significantly related (P < 0.003) to complications and not to cerebral malaria. There were 12 mortalities out of which 9 were due to MODS and 3 due to ARDS. Conclusions: 50.8% cases conformed to the WHO definition of severe malaria indicating most present with complications. High parasite index and abnormal renal function are predictors of mortality and complications. Early diagnosis, anticipation of complications, close monitoring and combination therapy to over come drug resistance helps to contain the extent of mortality.

Original languageEnglish
Pages (from-to)S81-S86
JournalAsian Pacific Journal of Tropical Biomedicine
Volume4
DOIs
Publication statusPublished - 01-01-2014

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Falciparum Malaria
Paramagnetic resonance
India
Statistical methods
Mortality
Monitoring
Pharmaceutical Preparations
Cerebral Malaria
Kidney
Multiple Organ Failure
Chi-Square Distribution
Jaundice
Hypoglycemia
Drug Resistance
Malaria
Vomiting
Renal Insufficiency
Anemia
Inpatients
Early Diagnosis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

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title = "The emerging trends of falciparum malaria: A study from a tertiary centre in an endemic area of India",
abstract = "Objective: To document the various clinical manifestations, lab parameters, complications and outcomes of Falciparum Malaria. The above data would be correlated with the parasitic index to deduce whether it would be an effective measure of the same. Methods: This was a prospective study among 183 inpatients aged above 18 from Kasturba Hospital, Manipal from May 2009 to January 2011. Ethical clearance was taken. Statistical analysis was done with the independent paired t test, linear correlation and Chi square test using SPSS 16. Results: In this study 78{\%} cases were males. Most cases occurred during the monsoons. Fever was the major presentation with others being jaundice, vomiting and head ache. 50.8 {\%} had complications, including hepatic dysfunction (40.9{\%}), renal failure (19.13{\%}), shock (7{\%}), altered sensorium (9{\%}), ARDS (3.27{\%}) and severe anemia (1.63{\%}). Hypoglycemia and gram negative sepsis were rare. Parasitic index, renal parameters and death were correlating positively. ESR was significantly related (P < 0.003) to complications and not to cerebral malaria. There were 12 mortalities out of which 9 were due to MODS and 3 due to ARDS. Conclusions: 50.8{\%} cases conformed to the WHO definition of severe malaria indicating most present with complications. High parasite index and abnormal renal function are predictors of mortality and complications. Early diagnosis, anticipation of complications, close monitoring and combination therapy to over come drug resistance helps to contain the extent of mortality.",
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The emerging trends of falciparum malaria : A study from a tertiary centre in an endemic area of India. / Poovathingal, Mary Anne; Nagiri, Shivashankara Kaniyoor; Nagaraja.

In: Asian Pacific Journal of Tropical Biomedicine, Vol. 4, 01.01.2014, p. S81-S86.

Research output: Contribution to journalArticle

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