The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro

A preliminary study

Ganesh Chandra Jagetia, Shaival Kamalaksh Rao, Manjeshwar Shrinath Baliga, Kiran S. Babu

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The nitric oxide (NO) scavenging activities of traditional polyherbal drugs like abana, chyavanaprasha, geriforte, septilin, mentat and triphala were examined using sodium nitroprusside as a NO donor in vitro. All the drugs tested demonstrated direct scavenging of NO and were superior to Gingko biloba, which was used as a positive control. The extracts of various polyherbal drugs exhibited dose-dependent NO scavenging activities and the potency was in the following order: abana > chyavanaprasha > triphala > geriforte > septilin > mentat > Gingko biloba. The present results suggest that the traditional Indian polyherbal crude drugs may be potent and novel therapeutic agents for scavenging of NO, and thereby inhibit the pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite. These findings may also help to explain, at least in part, the pharmacological activities like rejuvenating, adaptogenic, anti-infection, anti-inflammatory, cardioprotective and neuroprotective activities of these traditional, clinically used non toxic drugs.

Original languageEnglish
Pages (from-to)561-565
Number of pages5
JournalPhytotherapy Research
Volume18
Issue number7
DOIs
Publication statusPublished - 01-07-2004
Externally publishedYes

Fingerprint

Nitric Oxide
Ginkgo biloba
Pharmaceutical Preparations
Peroxynitrous Acid
Nitric Oxide Donors
Poisons
Nitroprusside
Anti-Inflammatory Agents
In Vitro Techniques
Pharmacology
Infection
abana
triphala
geriforte
septilin
Mentat
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Jagetia, Ganesh Chandra ; Rao, Shaival Kamalaksh ; Baliga, Manjeshwar Shrinath ; Babu, Kiran S. / The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro : A preliminary study. In: Phytotherapy Research. 2004 ; Vol. 18, No. 7. pp. 561-565.
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The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro : A preliminary study. / Jagetia, Ganesh Chandra; Rao, Shaival Kamalaksh; Baliga, Manjeshwar Shrinath; Babu, Kiran S.

In: Phytotherapy Research, Vol. 18, No. 7, 01.07.2004, p. 561-565.

Research output: Contribution to journalArticle

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