The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring

Dayanidhi Kumar; Dinesh Upadhya; Sujit Raj Salian; Satish B.S. Rao; Guruprasad Kalthur; Pratap Kumar; Satish K. Adiga

doi:10.1016/j.ejogrb.2012.09.021

The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring

Dayanidhi Kumar, Dinesh Upadhya, Sujit Raj Salian, Satish B.S. Rao, Guruprasad Kalthur, Pratap Kumar, Satish K. Adiga

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Objectives: To study the post-natal characteristics and the survival of offspring derived from DNA damaged sperm. Study design: This experimental prospective study was conducted on Swiss Albino mice (Mus musculus). Sperm DNA damage was induced by different doses of γ-irradiation in male mice who were then mated with healthy female mice. The post-natal characteristics including the survival of first generation offspring were studied and then correlated with the amount of paternal sperm DNA damage. Results: A significant reduction of survival in the early post-natal period was observed in the first generation offspring derived from the DNA damaged sperm, and a strong association was observed between the extent of sperm DNA damage and the survival of the offspring. Conclusion: The DNA damage load in sperm at the time of fertilization influences early post-natal survival of the mouse offspring.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	European Journal of Obstetrics Gynecology and Reproductive Biology
Volume	166
Issue number	2
DOIs	https://doi.org/10.1016/j.ejogrb.2012.09.021
Publication status	Published - 02-2013

All Science Journal Classification (ASJC) codes

Reproductive Medicine
Obstetrics and Gynaecology

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10.1016/j.ejogrb.2012.09.021

Cite this

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title = "The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring",

abstract = "Objectives: To study the post-natal characteristics and the survival of offspring derived from DNA damaged sperm. Study design: This experimental prospective study was conducted on Swiss Albino mice (Mus musculus). Sperm DNA damage was induced by different doses of γ-irradiation in male mice who were then mated with healthy female mice. The post-natal characteristics including the survival of first generation offspring were studied and then correlated with the amount of paternal sperm DNA damage. Results: A significant reduction of survival in the early post-natal period was observed in the first generation offspring derived from the DNA damaged sperm, and a strong association was observed between the extent of sperm DNA damage and the survival of the offspring. Conclusion: The DNA damage load in sperm at the time of fertilization influences early post-natal survival of the mouse offspring.",

author = "Dayanidhi Kumar and Dinesh Upadhya and Salian, {Sujit Raj} and Rao, {Satish B.S.} and Guruprasad Kalthur and Pratap Kumar and Adiga, {Satish K.}",

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T1 - The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring

AU - Kumar, Dayanidhi

AU - Upadhya, Dinesh

AU - Salian, Sujit Raj

AU - Rao, Satish B.S.

AU - Kalthur, Guruprasad

AU - Kumar, Pratap

AU - Adiga, Satish K.

PY - 2013/2

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AB - Objectives: To study the post-natal characteristics and the survival of offspring derived from DNA damaged sperm. Study design: This experimental prospective study was conducted on Swiss Albino mice (Mus musculus). Sperm DNA damage was induced by different doses of γ-irradiation in male mice who were then mated with healthy female mice. The post-natal characteristics including the survival of first generation offspring were studied and then correlated with the amount of paternal sperm DNA damage. Results: A significant reduction of survival in the early post-natal period was observed in the first generation offspring derived from the DNA damaged sperm, and a strong association was observed between the extent of sperm DNA damage and the survival of the offspring. Conclusion: The DNA damage load in sperm at the time of fertilization influences early post-natal survival of the mouse offspring.

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The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring

Abstract

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