Abstract

Objectives: To study the post-natal characteristics and the survival of offspring derived from DNA damaged sperm. Study design: This experimental prospective study was conducted on Swiss Albino mice (Mus musculus). Sperm DNA damage was induced by different doses of γ-irradiation in male mice who were then mated with healthy female mice. The post-natal characteristics including the survival of first generation offspring were studied and then correlated with the amount of paternal sperm DNA damage. Results: A significant reduction of survival in the early post-natal period was observed in the first generation offspring derived from the DNA damaged sperm, and a strong association was observed between the extent of sperm DNA damage and the survival of the offspring. Conclusion: The DNA damage load in sperm at the time of fertilization influences early post-natal survival of the mouse offspring.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume166
Issue number2
DOIs
Publication statusPublished - 02-2013

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DNA Damage
Spermatozoa
DNA
Fertilization
Research Design
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

@article{730c0acac71d49c39ebbae0988ebbf56,
title = "The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring",
abstract = "Objectives: To study the post-natal characteristics and the survival of offspring derived from DNA damaged sperm. Study design: This experimental prospective study was conducted on Swiss Albino mice (Mus musculus). Sperm DNA damage was induced by different doses of γ-irradiation in male mice who were then mated with healthy female mice. The post-natal characteristics including the survival of first generation offspring were studied and then correlated with the amount of paternal sperm DNA damage. Results: A significant reduction of survival in the early post-natal period was observed in the first generation offspring derived from the DNA damaged sperm, and a strong association was observed between the extent of sperm DNA damage and the survival of the offspring. Conclusion: The DNA damage load in sperm at the time of fertilization influences early post-natal survival of the mouse offspring.",
author = "Dayanidhi Kumar and Dinesh Upadhya and Salian, {Sujit Raj} and Rao, {Satish B.S.} and Guruprasad Kalthur and Pratap Kumar and Adiga, {Satish K.}",
year = "2013",
month = "2",
doi = "10.1016/j.ejogrb.2012.09.021",
language = "English",
volume = "166",
pages = "164--167",
journal = "European Journal of Obstetrics and Gynecology and Reproductive Biology",
issn = "0028-2243",
publisher = "Elsevier Ireland Ltd",
number = "2",

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TY - JOUR

T1 - The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring

AU - Kumar, Dayanidhi

AU - Upadhya, Dinesh

AU - Salian, Sujit Raj

AU - Rao, Satish B.S.

AU - Kalthur, Guruprasad

AU - Kumar, Pratap

AU - Adiga, Satish K.

PY - 2013/2

Y1 - 2013/2

N2 - Objectives: To study the post-natal characteristics and the survival of offspring derived from DNA damaged sperm. Study design: This experimental prospective study was conducted on Swiss Albino mice (Mus musculus). Sperm DNA damage was induced by different doses of γ-irradiation in male mice who were then mated with healthy female mice. The post-natal characteristics including the survival of first generation offspring were studied and then correlated with the amount of paternal sperm DNA damage. Results: A significant reduction of survival in the early post-natal period was observed in the first generation offspring derived from the DNA damaged sperm, and a strong association was observed between the extent of sperm DNA damage and the survival of the offspring. Conclusion: The DNA damage load in sperm at the time of fertilization influences early post-natal survival of the mouse offspring.

AB - Objectives: To study the post-natal characteristics and the survival of offspring derived from DNA damaged sperm. Study design: This experimental prospective study was conducted on Swiss Albino mice (Mus musculus). Sperm DNA damage was induced by different doses of γ-irradiation in male mice who were then mated with healthy female mice. The post-natal characteristics including the survival of first generation offspring were studied and then correlated with the amount of paternal sperm DNA damage. Results: A significant reduction of survival in the early post-natal period was observed in the first generation offspring derived from the DNA damaged sperm, and a strong association was observed between the extent of sperm DNA damage and the survival of the offspring. Conclusion: The DNA damage load in sperm at the time of fertilization influences early post-natal survival of the mouse offspring.

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JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

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SN - 0028-2243

IS - 2

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