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The gastroprotective activity of the ethanol extract of Ageratum conyzoides. / Shirwaikar, A.; Bhilegaonkar, P.M.; Malini, S.; Sharath Kumar, J.In: Journal of Ethnopharmacology, Vol. 86, No. 1, 2003, p. 117-121.
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TY - JOUR
T1 - The gastroprotective activity of the ethanol extract of Ageratum conyzoides
AU - Shirwaikar, A.
AU - Bhilegaonkar, P.M.
AU - Malini, S.
AU - Sharath Kumar, J.
N1 - Cited By :31 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576119, India; email: firstname.lastname@example.org Chemicals/CAS: alcohol, 64-17-5; famotidine, 76824-35-6; ibuprofen, 15687-27-1, 79261-49-7, 31121-93-4, 527688-20-6; misoprostol, 59122-46-2, 59122-48-4 References: Achola, K.J., Munenge, R.W., Activity of Ageratum conyzoides on isolated rat phrenic nerve diaphragm and blood pressure on anaesthetised rats (1997) International Journal of Pharmacogenetics, 35, pp. 31-37; Achola, K.J., Munenge, R.W., Bronchodilating and uterine activities of Ageratum conyzoides extracts (1998) Pharmaceutical Biology, 36 (2), pp. 93-96; Alarcon, D.L.L.C., Martin, M.J., Lacasa, C., Motilva, V., Antiulcerogenic activity of flavonoids and gastric protection (1994) Journal of Ethnopharmacology, 42, pp. 161-170; Andrew, H., Soll, M.D., Pathogenesis of peptic ulcer and implication of therapy (1990) The New England Journal of Medicine, 322 (13), pp. 909-916; Bandyopadhyay, U., Das, D., Bandyopadhyay, D., Bhattacharjee, M., Banerjee, R.K., Role of reactive oxygen species in mercaptomethylimidazole-induced gastric acid secretion and stress-induced gastric ulceration (1999) Current Science, 76, pp. 55-63; Correa, M.P., (1984) Dicionario das plantas uteis do Brazil, e das exiticas, 2, p. 139. , Ministerio da Agricultura Rio de Janerio, IBDF; Cruz, G.L., (1985) Dicionario das plantas uteis do Brazil, 3rd ed., , Civilizacao Brasileira, Rio de Janerio; Desai, J.K., Goyal, R.K., Parmar, N.S., Pathogenesis of peptic ulcer disease and current trends in therapy (1997) Indian Journal of Physiology and Pharmacology, 41 (1), pp. 3-15; Fraga, C.G., Mactino, U.S., Ferraro, G.E., Coussio, J.F., Boveris, A., Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence (1987) Biochemical Medicine and Metabolic Biology, 36, pp. 717-720; Ghosh, M.N., (1984) Fundamentals of Experimental Pharmacology, p. 153. , Scientific Book Agency, Calcutta; Githens, T.S., Drug Plants of Africa (1948) African Handbooks, 8, p. 59; Gonzalez, A.G., Aguiar, Z.E., Grillo, T.A., Luis, J.G., Rivera, A., Calle, J., Methoxy flavone from Ageratum conyzoides (1991) Phytochemistry, 30, p. 1269; Hardman, J.G., (1985) The Pharmacological Basis of Therapeutics, 9th ed., p. 356. , McGraw-Hill Publication, New York; Halliwell, B., Free radical, antioxidant and human disease: Curiosity, cause or constipation? (1994) Lancet, 334, pp. 721-724; Jain, S.M., Bhatt, R.V., Goyal, R.K., Santani, D.D., Parmar, N.S., Effects of verapamil on gastric ulcer in rats (1990) Indian Journal of Pharmacology, 22, pp. 253-255; Kirtikar, K.R., Basu, M.D., (1991) Indian Medicinal Plants, vol. 2, 2nd ed., 2, pp. 1330-1331. , Periodical Express Book Agency, New Delhi; Mallikarjuna Rao, C., Ramesh, K.V., Bairy, K.L., Kulkarni, D., Zinc complexes NSAIDS abolish gastric IC ulceration propensity of parent drugs (1990) Indian Drugs, 28 (2), p. 64; Mandal, S., Roy, R.K., Das, H.N., Aditya, G.N., Chattopadhayay, R.N., Lahiri, H.L., Maitra, S.K., Potentiation of gastric antiulcer effect of famotidine by calcium channel blockers in rats (1998) Indian Journal of Pharmacology, 30, pp. 390-393; Morimoto, Y., Shimohara, K., Oshima, S., Sukamoto, T., Effect of the new antiulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine (1991) Japanese Journal of Pharmacology, 57, pp. 495-505; Naito, Y., Yoshikawa, T., Matsuyama, K., Yagi, N., Aral, M., Nakamura, S., Yoshida, N., Konda, M., Effect of oxygen radical scavengers on the quality of gastric ulcer healing in rats (1995) Journal of Clinical Gastroenterology, 21, pp. 82-S86; Noumi, E., Dibakto, T.W., Medicinal plants used for peptic ulcer in the Bangangte region, Western Cameroon (2000) Fitoterapia, 71, pp. 406-412; Okunade, A.L., Review Ageratum conyzoides L. (Asteraceae) (2002) Fitoterapia, 2 (73), pp. 1-16; Parmar, N.S., Parmar, S., The antiulcer potential of flavonoids (1998) Indian Journal of Physiology and Pharmacology, 42, pp. 343-351; Quijano, L., Calderson, J.S., Gomez, G.F., Soria, I.E., Rios, T., Highly oxygenated flavonoids from Ageratum conyzoides (1980) Phytochemistry, 19 (11), p. 2439; Rao, C.M., Ramesh, K.V., Bairy, K.L., Kulkarni, D.R., Zinc complexes of NSAID's abolish gastric ulceration propensity of parent drugs (1990) Indian Drugs, 28, pp. 64-67; Ratty, A.K., Effects of flavonoids on non enzymatic lipid peroxidation: Structure-activity relationship (1988) Biochemical Medicine and Metabolic Biology, 39, pp. 67-69; Santosh, A.C., Vyemura, S.A., Lopes, J.L., Bajon, J.N., Mingatto, F.E., Curti, C., Effect of naturally occuring flavonoids on lipid peroxidation and membrane permeability transaction in mitochondria (1998) Free Radical Biology and Medicine, 24, pp. 1455-1461; Shah, A.H., Khan, Z.A., Gastroprotective effect of pretreatment with Zizyphus sativa fruits against toxic damage in rats (1997) Fitoterapia, 3, pp. 226-234; Soll, A.H., Pathogenesis of peptic ulcer and implications for therapy (1990) The New England Journal of Medicine, 322, pp. 909-916; Sreejayan, N., Rao, M.N.A., Nitric oxide scavenging by curcuminoids (1996) The Journal of Pharmacy and Pharmacology, 49, pp. 105-107; Takeuchi, K., Ueshima, K., Ohuchi, T., Okabe, S., The role of capsiacin sensitive sensory neurons in healing of HCl-induced mucosal lesions in rats (1994) Gastroenterology, 104, pp. 1524-1532; Turner, M.A., (1965) Screening Methods in Pharmacology, p. 26. , Academic Press, New York; Vincent, G.P., Body orientation food deprivation and potentiation of restraint induced gastric lesions (1977) Gastroenterologie Clinique et Biologique, 1, pp. 539-543; Vyas, A.S., Mulchandani, N.B., Polyoxygenated flavones from Ageratum conyzoides (1986) Phytochemistry, 25 (11), pp. 2625-2627; Yoganarnarasimham, S.N., (2000) Medicinal Plants of India - Tamil Nadu, 2, p. 27. , Regional Research Institute, Bangalore; Yang, H., Zhang, X.J., The role of brain 5-HT in genesis of stress induced gastric ulcer in rats (1985) Acta Physiologica Sinica, 37, pp. 416-426; Yang, H., Central serotonin influences the development of cold restraint stress induced gastric ulceration; role of autonomic and endocrine mechanism (1995) Gastrointestinal and Endocrine System, pp. 77-82. , Singer, M.V., Zieglar, R., Rohr, G. (Eds.), Kluwer, Academic Publishers, New York
PY - 2003
Y1 - 2003
N2 - The ethanol extract of Ageratum conyzoides was evaluated for gastroprotection in rats using the Ibuprofen, ethanol and cold restraint stress ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the ethanol extract at dose levels of 500 and 750mg/kg significantly protected gastric lesions by 80.59 and 89.33%, respectively, as compared to Misoprostol (74.43%) in the Ibuprofen model; by 97.09 and 99.24%, respectively, in the cold stress model as compared to Famotidine (77.86 and 92.71%) and by 86.58 and 92.29%, respectively, in the alcohol model. The findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity, Ca2+ channel blocking and antiserotogenic properties. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
AB - The ethanol extract of Ageratum conyzoides was evaluated for gastroprotection in rats using the Ibuprofen, ethanol and cold restraint stress ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the ethanol extract at dose levels of 500 and 750mg/kg significantly protected gastric lesions by 80.59 and 89.33%, respectively, as compared to Misoprostol (74.43%) in the Ibuprofen model; by 97.09 and 99.24%, respectively, in the cold stress model as compared to Famotidine (77.86 and 92.71%) and by 86.58 and 92.29%, respectively, in the alcohol model. The findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity, Ca2+ channel blocking and antiserotogenic properties. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
U2 - 10.1016/S0378-8741(03)00050-3
DO - 10.1016/S0378-8741(03)00050-3
M3 - Article
VL - 86
SP - 117
EP - 121
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 1