The gastroprotective activity of the ethanol extract of Ageratum conyzoides. / Shirwaikar, A.; Bhilegaonkar, P.M.; Malini, S.; Sharath Kumar, J.In: Journal of Ethnopharmacology, Vol. 86, No. 1, 2003, p. 117-121.
Research output: Contribution to journal › Article
TY - JOUR
T1 - The gastroprotective activity of the ethanol extract of Ageratum conyzoides
AU - Shirwaikar, A.
AU - Bhilegaonkar, P.M.
AU - Malini, S.
AU - Sharath Kumar, J.
N1 - Cited By :31 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576119, India; email: firstname.lastname@example.org Chemicals/CAS: alcohol, 64-17-5; famotidine, 76824-35-6; ibuprofen, 15687-27-1, 79261-49-7, 31121-93-4, 527688-20-6; misoprostol, 59122-46-2, 59122-48-4 References: Achola, K.J., Munenge, R.W., Activity of Ageratum conyzoides on isolated rat phrenic nerve diaphragm and blood pressure on anaesthetised rats (1997) International Journal of Pharmacogenetics, 35, pp. 31-37; Achola, K.J., Munenge, R.W., Bronchodilating and uterine activities of Ageratum conyzoides extracts (1998) Pharmaceutical Biology, 36 (2), pp. 93-96; Alarcon, D.L.L.C., Martin, M.J., Lacasa, C., Motilva, V., Antiulcerogenic activity of flavonoids and gastric protection (1994) Journal of Ethnopharmacology, 42, pp. 161-170; Andrew, H., Soll, M.D., Pathogenesis of peptic ulcer and implication of therapy (1990) The New England Journal of Medicine, 322 (13), pp. 909-916; Bandyopadhyay, U., Das, D., Bandyopadhyay, D., Bhattacharjee, M., Banerjee, R.K., Role of reactive oxygen species in mercaptomethylimidazole-induced gastric acid secretion and stress-induced gastric ulceration (1999) Current Science, 76, pp. 55-63; Correa, M.P., (1984) Dicionario das plantas uteis do Brazil, e das exiticas, 2, p. 139. , Ministerio da Agricultura Rio de Janerio, IBDF; Cruz, G.L., (1985) Dicionario das plantas uteis do Brazil, 3rd ed., , Civilizacao Brasileira, Rio de Janerio; Desai, J.K., Goyal, R.K., Parmar, N.S., Pathogenesis of peptic ulcer disease and current trends in therapy (1997) Indian Journal of Physiology and Pharmacology, 41 (1), pp. 3-15; Fraga, C.G., Mactino, U.S., Ferraro, G.E., Coussio, J.F., Boveris, A., Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence (1987) Biochemical Medicine and Metabolic Biology, 36, pp. 717-720; Ghosh, M.N., (1984) Fundamentals of Experimental Pharmacology, p. 153. , Scientific Book Agency, Calcutta; Githens, T.S., Drug Plants of Africa (1948) African Handbooks, 8, p. 59; Gonzalez, A.G., Aguiar, Z.E., Grillo, T.A., Luis, J.G., Rivera, A., Calle, J., Methoxy flavone from Ageratum conyzoides (1991) Phytochemistry, 30, p. 1269; Hardman, J.G., (1985) The Pharmacological Basis of Therapeutics, 9th ed., p. 356. , McGraw-Hill Publication, New York; Halliwell, B., Free radical, antioxidant and human disease: Curiosity, cause or constipation? 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(Eds.), Kluwer, Academic Publishers, New York
PY - 2003
Y1 - 2003
N2 - The ethanol extract of Ageratum conyzoides was evaluated for gastroprotection in rats using the Ibuprofen, ethanol and cold restraint stress ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the ethanol extract at dose levels of 500 and 750mg/kg significantly protected gastric lesions by 80.59 and 89.33%, respectively, as compared to Misoprostol (74.43%) in the Ibuprofen model; by 97.09 and 99.24%, respectively, in the cold stress model as compared to Famotidine (77.86 and 92.71%) and by 86.58 and 92.29%, respectively, in the alcohol model. The findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity, Ca2+ channel blocking and antiserotogenic properties. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
AB - The ethanol extract of Ageratum conyzoides was evaluated for gastroprotection in rats using the Ibuprofen, ethanol and cold restraint stress ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the ethanol extract at dose levels of 500 and 750mg/kg significantly protected gastric lesions by 80.59 and 89.33%, respectively, as compared to Misoprostol (74.43%) in the Ibuprofen model; by 97.09 and 99.24%, respectively, in the cold stress model as compared to Famotidine (77.86 and 92.71%) and by 86.58 and 92.29%, respectively, in the alcohol model. The findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity, Ca2+ channel blocking and antiserotogenic properties. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
U2 - 10.1016/S0378-8741(03)00050-3
DO - 10.1016/S0378-8741(03)00050-3
M3 - Article
VL - 86
SP - 117
EP - 121
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 1