The herbal preparation abana protects against radiation-induced micronuclei in mouse bone marrow

Ganesh Chandra Jagetia, R. Aruna

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The induction of micronuclei was studied in mouse bone marrow treated or not with 5, 10 and 20 mg/kg b.wt. of abana (a herbal preparation) before exposure to 0-3 Gy of γ-radiation. Whole-body irradiation of mice resulted in a dose-dependent increase in the frequency of micronuclei. Treatment of mice with various doses of abana before exposure to different doses of γ-rays resulted in a significant reduction of the micronucleus frequency at all exposure doses. The highest decline in the frequencies of micronuclei was observed after administration of 20 mg/kg abana, where the frequency of micronuclei was approximately 4-fold less than that of the concurrent control. The PCE/NCE ratio was significantly higher in the drug-treated group compared to DDW + irradiated control and it was almost restored to normal level after administration of 20 mg/kg abana. Our results demonstrate that abana protects mice against radiation-induced micronucleus formation and radiation-induced decline in cell proliferation.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume393
Issue number1-2
DOIs
Publication statusPublished - 18-09-1997
Externally publishedYes

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Plant Preparations
Bone Marrow
Radiation
Radiation Dosage
Whole-Body Irradiation
Cell Proliferation
abana
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

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abstract = "The induction of micronuclei was studied in mouse bone marrow treated or not with 5, 10 and 20 mg/kg b.wt. of abana (a herbal preparation) before exposure to 0-3 Gy of γ-radiation. Whole-body irradiation of mice resulted in a dose-dependent increase in the frequency of micronuclei. Treatment of mice with various doses of abana before exposure to different doses of γ-rays resulted in a significant reduction of the micronucleus frequency at all exposure doses. The highest decline in the frequencies of micronuclei was observed after administration of 20 mg/kg abana, where the frequency of micronuclei was approximately 4-fold less than that of the concurrent control. The PCE/NCE ratio was significantly higher in the drug-treated group compared to DDW + irradiated control and it was almost restored to normal level after administration of 20 mg/kg abana. Our results demonstrate that abana protects mice against radiation-induced micronucleus formation and radiation-induced decline in cell proliferation.",
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The herbal preparation abana protects against radiation-induced micronuclei in mouse bone marrow. / Chandra Jagetia, Ganesh; Aruna, R.

In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Vol. 393, No. 1-2, 18.09.1997, p. 157-163.

Research output: Contribution to journalArticle

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