The impact of chimerism in DNA-based forensic sex determination analysis

Renjith George, Preethy Mary Donald, Sumanth Kumbargere Nagraj, Jose Joy Idiculla, Rashid Hj Ismail

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sex determination is the most important step in personal identification in forensic investigations. DNA-based sex determination analysis is comparatively more reliable than the other conventional methods of sex determination analysis. Advanced technology like real-time polymerase chain reaction (PCR) offers accurate and reproducible results and is at the level of legal acceptance. But still there are situations like chimerism where an individual possess both male and female specific factors together in their body. Sex determination analysis in such cases can give erroneous results. This paper discusses the phenomenon of chimerism and its impact on sex determination analysis in forensic investigations.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalMalaysian Journal of Medical Sciences
Volume20
Issue number1
Publication statusPublished - 01-01-2013
Externally publishedYes

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Sex Determination Analysis
Chimerism
DNA
Real-Time Polymerase Chain Reaction
Technology

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

George, R., Donald, P. M., Nagraj, S. K., Idiculla, J. J., & Ismail, R. H. (2013). The impact of chimerism in DNA-based forensic sex determination analysis. Malaysian Journal of Medical Sciences, 20(1), 75-79.
George, Renjith ; Donald, Preethy Mary ; Nagraj, Sumanth Kumbargere ; Idiculla, Jose Joy ; Ismail, Rashid Hj. / The impact of chimerism in DNA-based forensic sex determination analysis. In: Malaysian Journal of Medical Sciences. 2013 ; Vol. 20, No. 1. pp. 75-79.
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George, R, Donald, PM, Nagraj, SK, Idiculla, JJ & Ismail, RH 2013, 'The impact of chimerism in DNA-based forensic sex determination analysis', Malaysian Journal of Medical Sciences, vol. 20, no. 1, pp. 75-79.

The impact of chimerism in DNA-based forensic sex determination analysis. / George, Renjith; Donald, Preethy Mary; Nagraj, Sumanth Kumbargere; Idiculla, Jose Joy; Ismail, Rashid Hj.

In: Malaysian Journal of Medical Sciences, Vol. 20, No. 1, 01.01.2013, p. 75-79.

Research output: Contribution to journalArticle

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George R, Donald PM, Nagraj SK, Idiculla JJ, Ismail RH. The impact of chimerism in DNA-based forensic sex determination analysis. Malaysian Journal of Medical Sciences. 2013 Jan 1;20(1):75-79.