The integration of genome-based information for common diseases into health policy and healthcare as a major challenge for Public Health Genomics

The example of the methylenetetrahydrofolate reductase gene in non-cancer diseases

Stefania Boccia, Angela Brand, Helmut Brand, Gualtiero Ricciardi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Whereas medicine is currently undergoing remarkable developments from its morphological and phenotype orientation to a molecular and genotype orientation, promoting the importance of prognosis and prediction, the discussion about the role of genome-based information for epidemiological research and public health still is at the beginning. Public Health Genomics (PHG) contributes to this discussion by focussing on the use of genome-based information for epidemiological research, surveillance systems, health policy development, individual health information management and effective health services. The article focuses on the role of the methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in non-cancer diseases to demonstrate the urgent need for a responsible and systematic translation of genome-based information into health policy and healthcare.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume667
Issue number1-2
DOIs
Publication statusPublished - 10-07-2009

Fingerprint

Methylenetetrahydrofolate Reductase (NADPH2)
Health Policy
Genomics
Public Health
Genome
Delivery of Health Care
Health Information Management
Genes
Policy Making
Research
Health Services
Genotype
Medicine
Phenotype

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

@article{a85e3fca628e4a7081b07509d8c8c524,
title = "The integration of genome-based information for common diseases into health policy and healthcare as a major challenge for Public Health Genomics: The example of the methylenetetrahydrofolate reductase gene in non-cancer diseases",
abstract = "Whereas medicine is currently undergoing remarkable developments from its morphological and phenotype orientation to a molecular and genotype orientation, promoting the importance of prognosis and prediction, the discussion about the role of genome-based information for epidemiological research and public health still is at the beginning. Public Health Genomics (PHG) contributes to this discussion by focussing on the use of genome-based information for epidemiological research, surveillance systems, health policy development, individual health information management and effective health services. The article focuses on the role of the methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in non-cancer diseases to demonstrate the urgent need for a responsible and systematic translation of genome-based information into health policy and healthcare.",
author = "Stefania Boccia and Angela Brand and Helmut Brand and Gualtiero Ricciardi",
year = "2009",
month = "7",
day = "10",
doi = "10.1016/j.mrfmmm.2008.10.003",
language = "English",
volume = "667",
pages = "27--34",
journal = "Mutation Research",
issn = "1386-1964",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - The integration of genome-based information for common diseases into health policy and healthcare as a major challenge for Public Health Genomics

T2 - The example of the methylenetetrahydrofolate reductase gene in non-cancer diseases

AU - Boccia, Stefania

AU - Brand, Angela

AU - Brand, Helmut

AU - Ricciardi, Gualtiero

PY - 2009/7/10

Y1 - 2009/7/10

N2 - Whereas medicine is currently undergoing remarkable developments from its morphological and phenotype orientation to a molecular and genotype orientation, promoting the importance of prognosis and prediction, the discussion about the role of genome-based information for epidemiological research and public health still is at the beginning. Public Health Genomics (PHG) contributes to this discussion by focussing on the use of genome-based information for epidemiological research, surveillance systems, health policy development, individual health information management and effective health services. The article focuses on the role of the methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in non-cancer diseases to demonstrate the urgent need for a responsible and systematic translation of genome-based information into health policy and healthcare.

AB - Whereas medicine is currently undergoing remarkable developments from its morphological and phenotype orientation to a molecular and genotype orientation, promoting the importance of prognosis and prediction, the discussion about the role of genome-based information for epidemiological research and public health still is at the beginning. Public Health Genomics (PHG) contributes to this discussion by focussing on the use of genome-based information for epidemiological research, surveillance systems, health policy development, individual health information management and effective health services. The article focuses on the role of the methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in non-cancer diseases to demonstrate the urgent need for a responsible and systematic translation of genome-based information into health policy and healthcare.

UR - http://www.scopus.com/inward/record.url?scp=67649205007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649205007&partnerID=8YFLogxK

U2 - 10.1016/j.mrfmmm.2008.10.003

DO - 10.1016/j.mrfmmm.2008.10.003

M3 - Article

VL - 667

SP - 27

EP - 34

JO - Mutation Research

JF - Mutation Research

SN - 1386-1964

IS - 1-2

ER -