The pattern of the initial anti-retroviral drug regimens in HIV patients at a tertiary care hospital

G. J.K. Prakash Raju, Mukta N. Chowta, Zahoor Ahmad Rather, Faheem Mubeen

Research output: Contribution to journalArticle

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Abstract

Background and objective: The choice of the anti-retroviral drug therapy has been evolving over the last decade. The objective of this study was to evaluate the current prescribing pattern of the anti-retroviral drugs in treatment-naïve patients before initiating the anti-retroviral therapy. Materials and Methods: A retrospective review of the antiretroviral drugs which had been prescribed to the HIV-infected patients was conducted at a tertiary care hospital in South India. Only adults patients who were of more than 18 years of age, with a positive serology, who had started or had already been receiving the anti-retroviral therapy were included. Their main demographics, the details of the AIDS diagnoses, the laboratory data (CD4 cell counts) and the history of the antiretroviral therapy were collected. Result: The total number of patients was 108. Among them, 76 (70.4%) were males and 32 (29.6%) were females. The mean age of the patients was 38.67 ±10.02years, the mean weight was 52.47± 11.2kg and the mean CD4 count was 256.57 ± 204.6cells/cumm. Among these patients, 34(31.5%) were on the lamivudine+ zidovudine+ nevirapine regimen, 70(64.8%) were on the lamnivudine + nevirapine+ stavudine regimen (3TC + NVP+ d4T) and 4(3.7%) were on the tenofovir+ emtricitabine +efavirenz regimen. In the first regimen, the mean age of the patients was 39.09 ±9.1years, the mean weight was 51.87±10.7kg and the mean CD4 count was 253.21±177.8cells/cumm. In the second regimen, the mean age of the patients was 38.73 ±10.59 years, the mean weight was 52.37±12.24kg and the mean CD4 count was 262.02± 221.4 cells /cumm. The comparison of the mean age and the mean CD4 count among the patients in the different regimens did not show any statistical significance. Conclusion: The most frequently used antiretroviral drug regimen was the 3TC + NVP+ d4T combination. The prescription pattern was quite in contrast to that which was followed in the developed countries. Newer NRTIs were less frequently used.

Original languageEnglish
Pages (from-to)1178-1180
Number of pages3
JournalJournal of Clinical and Diagnostic Research
Volume6
Issue number7 SUPPL.
Publication statusPublished - 30-09-2012

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Lamivudine
Tertiary Healthcare
Tertiary Care Centers
Nevirapine
Tenofovir
efavirenz
HIV
CD4 Lymphocyte Count
Pharmaceutical Preparations
Patient treatment
Stavudine
Drug therapy
Zidovudine
Weights and Measures
Clinical Laboratory Techniques
Serology
Therapeutics
Developed Countries
Prescriptions
India

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Prakash Raju, G. J.K. ; Chowta, Mukta N. ; Rather, Zahoor Ahmad ; Mubeen, Faheem. / The pattern of the initial anti-retroviral drug regimens in HIV patients at a tertiary care hospital. In: Journal of Clinical and Diagnostic Research. 2012 ; Vol. 6, No. 7 SUPPL. pp. 1178-1180.
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abstract = "Background and objective: The choice of the anti-retroviral drug therapy has been evolving over the last decade. The objective of this study was to evaluate the current prescribing pattern of the anti-retroviral drugs in treatment-na{\"i}ve patients before initiating the anti-retroviral therapy. Materials and Methods: A retrospective review of the antiretroviral drugs which had been prescribed to the HIV-infected patients was conducted at a tertiary care hospital in South India. Only adults patients who were of more than 18 years of age, with a positive serology, who had started or had already been receiving the anti-retroviral therapy were included. Their main demographics, the details of the AIDS diagnoses, the laboratory data (CD4 cell counts) and the history of the antiretroviral therapy were collected. Result: The total number of patients was 108. Among them, 76 (70.4{\%}) were males and 32 (29.6{\%}) were females. The mean age of the patients was 38.67 ±10.02years, the mean weight was 52.47± 11.2kg and the mean CD4 count was 256.57 ± 204.6cells/cumm. Among these patients, 34(31.5{\%}) were on the lamivudine+ zidovudine+ nevirapine regimen, 70(64.8{\%}) were on the lamnivudine + nevirapine+ stavudine regimen (3TC + NVP+ d4T) and 4(3.7{\%}) were on the tenofovir+ emtricitabine +efavirenz regimen. In the first regimen, the mean age of the patients was 39.09 ±9.1years, the mean weight was 51.87±10.7kg and the mean CD4 count was 253.21±177.8cells/cumm. In the second regimen, the mean age of the patients was 38.73 ±10.59 years, the mean weight was 52.37±12.24kg and the mean CD4 count was 262.02± 221.4 cells /cumm. The comparison of the mean age and the mean CD4 count among the patients in the different regimens did not show any statistical significance. Conclusion: The most frequently used antiretroviral drug regimen was the 3TC + NVP+ d4T combination. The prescription pattern was quite in contrast to that which was followed in the developed countries. Newer NRTIs were less frequently used.",
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The pattern of the initial anti-retroviral drug regimens in HIV patients at a tertiary care hospital. / Prakash Raju, G. J.K.; Chowta, Mukta N.; Rather, Zahoor Ahmad; Mubeen, Faheem.

In: Journal of Clinical and Diagnostic Research, Vol. 6, No. 7 SUPPL., 30.09.2012, p. 1178-1180.

Research output: Contribution to journalArticle

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T1 - The pattern of the initial anti-retroviral drug regimens in HIV patients at a tertiary care hospital

AU - Prakash Raju, G. J.K.

AU - Chowta, Mukta N.

AU - Rather, Zahoor Ahmad

AU - Mubeen, Faheem

PY - 2012/9/30

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N2 - Background and objective: The choice of the anti-retroviral drug therapy has been evolving over the last decade. The objective of this study was to evaluate the current prescribing pattern of the anti-retroviral drugs in treatment-naïve patients before initiating the anti-retroviral therapy. Materials and Methods: A retrospective review of the antiretroviral drugs which had been prescribed to the HIV-infected patients was conducted at a tertiary care hospital in South India. Only adults patients who were of more than 18 years of age, with a positive serology, who had started or had already been receiving the anti-retroviral therapy were included. Their main demographics, the details of the AIDS diagnoses, the laboratory data (CD4 cell counts) and the history of the antiretroviral therapy were collected. Result: The total number of patients was 108. Among them, 76 (70.4%) were males and 32 (29.6%) were females. The mean age of the patients was 38.67 ±10.02years, the mean weight was 52.47± 11.2kg and the mean CD4 count was 256.57 ± 204.6cells/cumm. Among these patients, 34(31.5%) were on the lamivudine+ zidovudine+ nevirapine regimen, 70(64.8%) were on the lamnivudine + nevirapine+ stavudine regimen (3TC + NVP+ d4T) and 4(3.7%) were on the tenofovir+ emtricitabine +efavirenz regimen. In the first regimen, the mean age of the patients was 39.09 ±9.1years, the mean weight was 51.87±10.7kg and the mean CD4 count was 253.21±177.8cells/cumm. In the second regimen, the mean age of the patients was 38.73 ±10.59 years, the mean weight was 52.37±12.24kg and the mean CD4 count was 262.02± 221.4 cells /cumm. The comparison of the mean age and the mean CD4 count among the patients in the different regimens did not show any statistical significance. Conclusion: The most frequently used antiretroviral drug regimen was the 3TC + NVP+ d4T combination. The prescription pattern was quite in contrast to that which was followed in the developed countries. Newer NRTIs were less frequently used.

AB - Background and objective: The choice of the anti-retroviral drug therapy has been evolving over the last decade. The objective of this study was to evaluate the current prescribing pattern of the anti-retroviral drugs in treatment-naïve patients before initiating the anti-retroviral therapy. Materials and Methods: A retrospective review of the antiretroviral drugs which had been prescribed to the HIV-infected patients was conducted at a tertiary care hospital in South India. Only adults patients who were of more than 18 years of age, with a positive serology, who had started or had already been receiving the anti-retroviral therapy were included. Their main demographics, the details of the AIDS diagnoses, the laboratory data (CD4 cell counts) and the history of the antiretroviral therapy were collected. Result: The total number of patients was 108. Among them, 76 (70.4%) were males and 32 (29.6%) were females. The mean age of the patients was 38.67 ±10.02years, the mean weight was 52.47± 11.2kg and the mean CD4 count was 256.57 ± 204.6cells/cumm. Among these patients, 34(31.5%) were on the lamivudine+ zidovudine+ nevirapine regimen, 70(64.8%) were on the lamnivudine + nevirapine+ stavudine regimen (3TC + NVP+ d4T) and 4(3.7%) were on the tenofovir+ emtricitabine +efavirenz regimen. In the first regimen, the mean age of the patients was 39.09 ±9.1years, the mean weight was 51.87±10.7kg and the mean CD4 count was 253.21±177.8cells/cumm. In the second regimen, the mean age of the patients was 38.73 ±10.59 years, the mean weight was 52.37±12.24kg and the mean CD4 count was 262.02± 221.4 cells /cumm. The comparison of the mean age and the mean CD4 count among the patients in the different regimens did not show any statistical significance. Conclusion: The most frequently used antiretroviral drug regimen was the 3TC + NVP+ d4T combination. The prescription pattern was quite in contrast to that which was followed in the developed countries. Newer NRTIs were less frequently used.

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