The promise of discovering population-specific disease-associated genes in South Asia

Nathan Nakatsuka, Priya Moorjani, Niraj Rai, Biswanath Sarkar, Arti Tandon, Nick Patterson, Gandham Srilakshmi Bhavani, Katta Mohan Girisha, Mohammed S. Mustak, Sudha Srinivasan, Amit Kaushik, Saadi Abdul Vahab, Sujatha M. Jagadeesh, Kapaettu Satyamoorthy, Lalji Singh, David Reich, Kumarasamy Thangaraj

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Abstract

The more than 1.5 billion people who live in South Asia are correctly viewed not as a single large population but as many small endogamous groups. We assembled genome-wide data from over 2,800 individuals from over 260 distinct South Asian groups. We identified 81 unique groups, 14 of which had estimated census sizes of more than 1 million, that descend from founder events more extreme than those in Ashkenazi Jews and Finns, both of which have high rates of recessive disease due to founder events. We identified multiple examples of recessive diseases in South Asia that are the result of such founder events. This study highlights an underappreciated opportunity for decreasing disease burden among South Asians through discovery of and testing for recessive disease-associated genes.

Original languageEnglish
Pages (from-to)1403-1407
Number of pages5
JournalNature Genetics
Volume49
Issue number9
DOIs
Publication statusPublished - 01-09-2017

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Population
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Jews
Censuses
Genome

All Science Journal Classification (ASJC) codes

  • Genetics

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Nakatsuka, N., Moorjani, P., Rai, N., Sarkar, B., Tandon, A., Patterson, N., ... Thangaraj, K. (2017). The promise of discovering population-specific disease-associated genes in South Asia. Nature Genetics, 49(9), 1403-1407. https://doi.org/10.1038/ng.3917
Nakatsuka, Nathan ; Moorjani, Priya ; Rai, Niraj ; Sarkar, Biswanath ; Tandon, Arti ; Patterson, Nick ; Bhavani, Gandham Srilakshmi ; Girisha, Katta Mohan ; Mustak, Mohammed S. ; Srinivasan, Sudha ; Kaushik, Amit ; Vahab, Saadi Abdul ; Jagadeesh, Sujatha M. ; Satyamoorthy, Kapaettu ; Singh, Lalji ; Reich, David ; Thangaraj, Kumarasamy. / The promise of discovering population-specific disease-associated genes in South Asia. In: Nature Genetics. 2017 ; Vol. 49, No. 9. pp. 1403-1407.
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Nakatsuka, N, Moorjani, P, Rai, N, Sarkar, B, Tandon, A, Patterson, N, Bhavani, GS, Girisha, KM, Mustak, MS, Srinivasan, S, Kaushik, A, Vahab, SA, Jagadeesh, SM, Satyamoorthy, K, Singh, L, Reich, D & Thangaraj, K 2017, 'The promise of discovering population-specific disease-associated genes in South Asia', Nature Genetics, vol. 49, no. 9, pp. 1403-1407. https://doi.org/10.1038/ng.3917

The promise of discovering population-specific disease-associated genes in South Asia. / Nakatsuka, Nathan; Moorjani, Priya; Rai, Niraj; Sarkar, Biswanath; Tandon, Arti; Patterson, Nick; Bhavani, Gandham Srilakshmi; Girisha, Katta Mohan; Mustak, Mohammed S.; Srinivasan, Sudha; Kaushik, Amit; Vahab, Saadi Abdul; Jagadeesh, Sujatha M.; Satyamoorthy, Kapaettu; Singh, Lalji; Reich, David; Thangaraj, Kumarasamy.

In: Nature Genetics, Vol. 49, No. 9, 01.09.2017, p. 1403-1407.

Research output: Contribution to journalArticle

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Nakatsuka N, Moorjani P, Rai N, Sarkar B, Tandon A, Patterson N et al. The promise of discovering population-specific disease-associated genes in South Asia. Nature Genetics. 2017 Sep 1;49(9):1403-1407. https://doi.org/10.1038/ng.3917