The role of histone deacetylases in embryonic development

Priyanka Dsilva, Padmini Pai, Manasa Gangadhar Shetty, Kampa S. Babitha

Research output: Contribution to journalReview articlepeer-review

Abstract

The basic units of chromatin are nucleosomes, that are made up of DNA wrapped around histone cores. Histone lysine residue is a common location for posttranslational modifications, with acetylation being the second most prevalent. Histone acetyltransferases (HATs/KATs) and histone deacetylases (HDACs/KDACs) regulate histone acetylation, which is important in gene expression control. HDACs/KDACs regulate gene expressions through the repression of the transcription machinery. HDAC/KDAC isoforms play a major role during various stages of embryo development and neurogenesis. In specific, class I and II HDACs/KDACs are involved in cardiac muscle differentiation and development. An insight into different pathways and genes associated with embryonic development, the effect of HDAC/KDAC activity during the embryonic stem cell differentiation, preimplantation, embryo development, gastrulation, and the role of different HDAC/KDAC inhibitors during the process of embryogenesis is summarized in the present review article.

Original languageEnglish
JournalMolecular Reproduction and Development
DOIs
Publication statusAccepted/In press - 2022

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'The role of histone deacetylases in embryonic development'. Together they form a unique fingerprint.

Cite this