TY - JOUR
T1 - The role of tumor-educated platelets in ovarian cancer
T2 - A comprehensive review and update
AU - Patel, Dimple
AU - Thankachan, Sanu
AU - Sreeram, Saraswathy
AU - Kavitha, K. P.
AU - Suresh, Padmanaban S.
N1 - Funding Information:
PSS acknowledges the National Institute of Technology, Calicut, Kerala, India (Faculty research seed grant) for their support and encouragement. ST acknowledges the fellowship support from the Ministry of Education, Govt. of India, and the National Institute of Technology, Calicut .
Funding Information:
PSS acknowledges the National Institute of Technology, Calicut, Kerala, India (Faculty research seed grant) for their support and encouragement. ST acknowledges the fellowship support from the Ministry of Education, Govt. of India, and the National Institute of Technology, Calicut.
Publisher Copyright:
© 2022 Elsevier GmbH
PY - 2023/1
Y1 - 2023/1
N2 - Platelets have recently surfaced as critical players in cancer metastasis and the local and systemic responses to tumor growth. The emerging concept of “Tumor-educated platelets (TEPs)” comprises the exchange of biomolecules between tumor cells and platelets, thereby leading to the “education” of platelets. Increased platelet numbers have long been associated with cancer patients' tumor metastasis and poor clinical prognosis. However, it is very recently that researchers have delved deeper into the tumor-microenvironment and probed the mechanism of interactions between tumor cells and platelets. Designing strategies to target the TEPs and the communications between platelets and tumor cells can prove to be a promising breakthrough in cancer therapy. Through this review, we aim to analyze the recent developments in this field and discuss the characteristics of TEPs, focusing on ovarian cancer-associated TEPs and their characteristics, the interplay between ovarian cancer-associated TEPs and cancer cells, and the purview of TEP-targeted cancer diagnosis and therapy, including platelet biomarkers and inhibitors.
AB - Platelets have recently surfaced as critical players in cancer metastasis and the local and systemic responses to tumor growth. The emerging concept of “Tumor-educated platelets (TEPs)” comprises the exchange of biomolecules between tumor cells and platelets, thereby leading to the “education” of platelets. Increased platelet numbers have long been associated with cancer patients' tumor metastasis and poor clinical prognosis. However, it is very recently that researchers have delved deeper into the tumor-microenvironment and probed the mechanism of interactions between tumor cells and platelets. Designing strategies to target the TEPs and the communications between platelets and tumor cells can prove to be a promising breakthrough in cancer therapy. Through this review, we aim to analyze the recent developments in this field and discuss the characteristics of TEPs, focusing on ovarian cancer-associated TEPs and their characteristics, the interplay between ovarian cancer-associated TEPs and cancer cells, and the purview of TEP-targeted cancer diagnosis and therapy, including platelet biomarkers and inhibitors.
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U2 - 10.1016/j.prp.2022.154267
DO - 10.1016/j.prp.2022.154267
M3 - Review article
AN - SCOPUS:85143760555
VL - 241
JO - Pathology Research and Practice
JF - Pathology Research and Practice
SN - 0344-0338
M1 - 154267
ER -
