The therapeutic potential of curcumin: A review of clinical trials

Bahare Salehi, Zorica Stojanović-Radić, Jelena Matejić, Mehdi Sharifi-Rad, Nanjangud V. Anil Kumar, Natália Martins, Javad Sharifi-Rad

Research output: Contribution to journalReview article

56 Citations (Scopus)

Abstract

Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases.

Original languageEnglish
Pages (from-to)527-545
Number of pages19
JournalEuropean Journal of Medicinal Chemistry
DOIs
Publication statusPublished - 01-02-2019

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Salehi, B., Stojanović-Radić, Z., Matejić, J., Sharifi-Rad, M., Anil Kumar, N. V., Martins, N., & Sharifi-Rad, J. (2019). The therapeutic potential of curcumin: A review of clinical trials. European Journal of Medicinal Chemistry, 527-545. https://doi.org/10.1016/j.ejmech.2018.12.016