The therapeutic potential of the labdane diterpenoid forskolin

Bahare Salehi; Mariola Staniak; Katarzyna Czopek; Anna Stepień; Kamal Dua; Ridhima Wadhwa; Dinesh Kumar Chellappan; Oksana Sytar; Marian Brestic; Namrata Ganesh Bhat; Nanjangud Venkatesh Anil Kumar; María del Mar Contreras; Farukh Sharopov; William C. Cho; Javad Sharifi-Rad

doi:10.3390/app9194089

The therapeutic potential of the labdane diterpenoid forskolin

Bahare Salehi, Mariola Staniak, Katarzyna Czopek, Anna Stepień, Kamal Dua, Ridhima Wadhwa, Dinesh Kumar Chellappan, Oksana Sytar, Marian Brestic, Namrata Ganesh Bhat, Nanjangud Venkatesh Anil Kumar, María del Mar Contreras, Farukh Sharopov, William C. Cho, Javad Sharifi-Rad

Department of Chemistry, Manipal Institute of Technology, Manipal

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.

Original language	English
Article number	4089
Journal	Applied Sciences (Switzerland)
Volume	9
Issue number	19
DOIs	https://doi.org/10.3390/app9194089
Publication status	Published - 01-10-2019

All Science Journal Classification (ASJC) codes

Materials Science(all)
Instrumentation
Engineering(all)
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/app9194089

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title = "The therapeutic potential of the labdane diterpenoid forskolin",

abstract = "Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.",

author = "Bahare Salehi and Mariola Staniak and Katarzyna Czopek and Anna Stepie{\'n} and Kamal Dua and Ridhima Wadhwa and Chellappan, {Dinesh Kumar} and Oksana Sytar and Marian Brestic and Bhat, {Namrata Ganesh} and Kumar, {Nanjangud Venkatesh Anil} and Contreras, {Mar{\'i}a del Mar} and Farukh Sharopov and Cho, {William C.} and Javad Sharifi-Rad",

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doi = "10.3390/app9194089",

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T1 - The therapeutic potential of the labdane diterpenoid forskolin

AU - Salehi, Bahare

AU - Staniak, Mariola

AU - Czopek, Katarzyna

AU - Stepień, Anna

AU - Dua, Kamal

AU - Wadhwa, Ridhima

AU - Chellappan, Dinesh Kumar

AU - Sytar, Oksana

AU - Brestic, Marian

AU - Bhat, Namrata Ganesh

AU - Kumar, Nanjangud Venkatesh Anil

AU - Contreras, María del Mar

AU - Sharopov, Farukh

AU - Cho, William C.

AU - Sharifi-Rad, Javad

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.

AB - Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.

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DO - 10.3390/app9194089

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VL - 9

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 19

M1 - 4089

ER -

The therapeutic potential of the labdane diterpenoid forskolin

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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