The Young Myocardial Infarction Study of the Western Indians

YOUTH Registry

Anand N. Shukla, Ashwal A. Jayaram, Dhaval Doshi, Priyanka Patel, Komal Shah, Alok Shinde, Harsh Ghoniya, Karthik Natarajan, Tarun Bansal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Myocardial infarction is among the leading causes of morbidity and mortality in young adults around the world. Objectives: In the YOUTH (Young Myocardial Infarction Study of the Western Indians) registry, we aimed to evaluate risk factor profile and angiographic outcomes of reperfusion therapies of infarct-related artery in young western Indians (≤40 years) having ST-segment elevation myocardial infarction. Methods: A total of 1,179 consecutive patients aged ≤40 years who presented with ischemic heart disease from June 2012 to December 2014 were enrolled in the YOUTH registry. A total of 787 patients with ST-segment elevation myocardial infarction were further evaluated. Categorical data was assessed using chi-square test, whereas continuous data was assessed using Student's t test. Regression analysis was performed to investigate the strength of association. Results: In the YOUTH registry, the study population was predominantly male (93%) with tobacco consumption as major prevalent risk factor (49.7%). Of 787 patients, 451 (57.31%) were thrombolyzed, 326 (41.42%) did not receive any reperfusion therapy, and 10 patients (1.27%) underwent primary angioplasty. Younger age, window period <6 h, and lower lipoprotein (a) level were observed in patients with a recanalized infarct-related artery. Regression analysis showed window period of thrombolysis as strongest predictor (odds ratio: 1.790, 95% confidence interval: 1.144–2.802; p < 0.011) of successful reperfusion. Patients (n = 235) being thrombolyzed in a window period of <6 h, had higher rate of infarct-related artery recanalization (77%) as compared to those with ≥6 h window period (23%). In-hospital mortality was 0.38% (n = 3), whereas bleeding complication was noted only in 1 patient. Conclusions: We herewith conclude that acute short-term outcome is favorable in young ST-segment elevation myocardial infarction patients, particularly in those who had received timely thrombolytic therapy. Though tobacco consumption was a major contributor of risk in young adults, prevalence of other risk factors was low in young Western Indians.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalGlobal Heart
Volume14
Issue number1
DOIs
Publication statusPublished - 01-03-2019

Fingerprint

Registries
Myocardial Infarction
Reperfusion
Arteries
Tobacco Use
Young Adult
Regression Analysis
Lipoprotein(a)
Thrombolytic Therapy
Chi-Square Distribution
Hospital Mortality
Angioplasty
Myocardial Ischemia
Odds Ratio
Confidence Intervals
Hemorrhage
Students
Morbidity
Mortality
Therapeutics

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Community and Home Care
  • Cardiology and Cardiovascular Medicine

Cite this

Shukla, A. N., Jayaram, A. A., Doshi, D., Patel, P., Shah, K., Shinde, A., ... Bansal, T. (2019). The Young Myocardial Infarction Study of the Western Indians: YOUTH Registry. Global Heart, 14(1), 27-33. https://doi.org/10.1016/j.gheart.2018.12.001
Shukla, Anand N. ; Jayaram, Ashwal A. ; Doshi, Dhaval ; Patel, Priyanka ; Shah, Komal ; Shinde, Alok ; Ghoniya, Harsh ; Natarajan, Karthik ; Bansal, Tarun. / The Young Myocardial Infarction Study of the Western Indians : YOUTH Registry. In: Global Heart. 2019 ; Vol. 14, No. 1. pp. 27-33.
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abstract = "Background: Myocardial infarction is among the leading causes of morbidity and mortality in young adults around the world. Objectives: In the YOUTH (Young Myocardial Infarction Study of the Western Indians) registry, we aimed to evaluate risk factor profile and angiographic outcomes of reperfusion therapies of infarct-related artery in young western Indians (≤40 years) having ST-segment elevation myocardial infarction. Methods: A total of 1,179 consecutive patients aged ≤40 years who presented with ischemic heart disease from June 2012 to December 2014 were enrolled in the YOUTH registry. A total of 787 patients with ST-segment elevation myocardial infarction were further evaluated. Categorical data was assessed using chi-square test, whereas continuous data was assessed using Student's t test. Regression analysis was performed to investigate the strength of association. Results: In the YOUTH registry, the study population was predominantly male (93{\%}) with tobacco consumption as major prevalent risk factor (49.7{\%}). Of 787 patients, 451 (57.31{\%}) were thrombolyzed, 326 (41.42{\%}) did not receive any reperfusion therapy, and 10 patients (1.27{\%}) underwent primary angioplasty. Younger age, window period <6 h, and lower lipoprotein (a) level were observed in patients with a recanalized infarct-related artery. Regression analysis showed window period of thrombolysis as strongest predictor (odds ratio: 1.790, 95{\%} confidence interval: 1.144–2.802; p < 0.011) of successful reperfusion. Patients (n = 235) being thrombolyzed in a window period of <6 h, had higher rate of infarct-related artery recanalization (77{\%}) as compared to those with ≥6 h window period (23{\%}). In-hospital mortality was 0.38{\%} (n = 3), whereas bleeding complication was noted only in 1 patient. Conclusions: We herewith conclude that acute short-term outcome is favorable in young ST-segment elevation myocardial infarction patients, particularly in those who had received timely thrombolytic therapy. Though tobacco consumption was a major contributor of risk in young adults, prevalence of other risk factors was low in young Western Indians.",
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Shukla, AN, Jayaram, AA, Doshi, D, Patel, P, Shah, K, Shinde, A, Ghoniya, H, Natarajan, K & Bansal, T 2019, 'The Young Myocardial Infarction Study of the Western Indians: YOUTH Registry', Global Heart, vol. 14, no. 1, pp. 27-33. https://doi.org/10.1016/j.gheart.2018.12.001

The Young Myocardial Infarction Study of the Western Indians : YOUTH Registry. / Shukla, Anand N.; Jayaram, Ashwal A.; Doshi, Dhaval; Patel, Priyanka; Shah, Komal; Shinde, Alok; Ghoniya, Harsh; Natarajan, Karthik; Bansal, Tarun.

In: Global Heart, Vol. 14, No. 1, 01.03.2019, p. 27-33.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Young Myocardial Infarction Study of the Western Indians

T2 - YOUTH Registry

AU - Shukla, Anand N.

AU - Jayaram, Ashwal A.

AU - Doshi, Dhaval

AU - Patel, Priyanka

AU - Shah, Komal

AU - Shinde, Alok

AU - Ghoniya, Harsh

AU - Natarajan, Karthik

AU - Bansal, Tarun

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: Myocardial infarction is among the leading causes of morbidity and mortality in young adults around the world. Objectives: In the YOUTH (Young Myocardial Infarction Study of the Western Indians) registry, we aimed to evaluate risk factor profile and angiographic outcomes of reperfusion therapies of infarct-related artery in young western Indians (≤40 years) having ST-segment elevation myocardial infarction. Methods: A total of 1,179 consecutive patients aged ≤40 years who presented with ischemic heart disease from June 2012 to December 2014 were enrolled in the YOUTH registry. A total of 787 patients with ST-segment elevation myocardial infarction were further evaluated. Categorical data was assessed using chi-square test, whereas continuous data was assessed using Student's t test. Regression analysis was performed to investigate the strength of association. Results: In the YOUTH registry, the study population was predominantly male (93%) with tobacco consumption as major prevalent risk factor (49.7%). Of 787 patients, 451 (57.31%) were thrombolyzed, 326 (41.42%) did not receive any reperfusion therapy, and 10 patients (1.27%) underwent primary angioplasty. Younger age, window period <6 h, and lower lipoprotein (a) level were observed in patients with a recanalized infarct-related artery. Regression analysis showed window period of thrombolysis as strongest predictor (odds ratio: 1.790, 95% confidence interval: 1.144–2.802; p < 0.011) of successful reperfusion. Patients (n = 235) being thrombolyzed in a window period of <6 h, had higher rate of infarct-related artery recanalization (77%) as compared to those with ≥6 h window period (23%). In-hospital mortality was 0.38% (n = 3), whereas bleeding complication was noted only in 1 patient. Conclusions: We herewith conclude that acute short-term outcome is favorable in young ST-segment elevation myocardial infarction patients, particularly in those who had received timely thrombolytic therapy. Though tobacco consumption was a major contributor of risk in young adults, prevalence of other risk factors was low in young Western Indians.

AB - Background: Myocardial infarction is among the leading causes of morbidity and mortality in young adults around the world. Objectives: In the YOUTH (Young Myocardial Infarction Study of the Western Indians) registry, we aimed to evaluate risk factor profile and angiographic outcomes of reperfusion therapies of infarct-related artery in young western Indians (≤40 years) having ST-segment elevation myocardial infarction. Methods: A total of 1,179 consecutive patients aged ≤40 years who presented with ischemic heart disease from June 2012 to December 2014 were enrolled in the YOUTH registry. A total of 787 patients with ST-segment elevation myocardial infarction were further evaluated. Categorical data was assessed using chi-square test, whereas continuous data was assessed using Student's t test. Regression analysis was performed to investigate the strength of association. Results: In the YOUTH registry, the study population was predominantly male (93%) with tobacco consumption as major prevalent risk factor (49.7%). Of 787 patients, 451 (57.31%) were thrombolyzed, 326 (41.42%) did not receive any reperfusion therapy, and 10 patients (1.27%) underwent primary angioplasty. Younger age, window period <6 h, and lower lipoprotein (a) level were observed in patients with a recanalized infarct-related artery. Regression analysis showed window period of thrombolysis as strongest predictor (odds ratio: 1.790, 95% confidence interval: 1.144–2.802; p < 0.011) of successful reperfusion. Patients (n = 235) being thrombolyzed in a window period of <6 h, had higher rate of infarct-related artery recanalization (77%) as compared to those with ≥6 h window period (23%). In-hospital mortality was 0.38% (n = 3), whereas bleeding complication was noted only in 1 patient. Conclusions: We herewith conclude that acute short-term outcome is favorable in young ST-segment elevation myocardial infarction patients, particularly in those who had received timely thrombolytic therapy. Though tobacco consumption was a major contributor of risk in young adults, prevalence of other risk factors was low in young Western Indians.

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