The Young Myocardial Infarction Study of the Western Indians: YOUTH Registry

Anand N. Shukla, Ashwal A. Jayaram, Dhaval Doshi, Priyanka Patel, Komal Shah, Alok Shinde, Harsh Ghoniya, Karthik Natarajan, Tarun Bansal

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3 Citations (Scopus)

Abstract

Background: Myocardial infarction is among the leading causes of morbidity and mortality in young adults around the world. Objectives: In the YOUTH (Young Myocardial Infarction Study of the Western Indians) registry, we aimed to evaluate risk factor profile and angiographic outcomes of reperfusion therapies of infarct-related artery in young western Indians (≤40 years) having ST-segment elevation myocardial infarction. Methods: A total of 1,179 consecutive patients aged ≤40 years who presented with ischemic heart disease from June 2012 to December 2014 were enrolled in the YOUTH registry. A total of 787 patients with ST-segment elevation myocardial infarction were further evaluated. Categorical data was assessed using chi-square test, whereas continuous data was assessed using Student's t test. Regression analysis was performed to investigate the strength of association. Results: In the YOUTH registry, the study population was predominantly male (93%) with tobacco consumption as major prevalent risk factor (49.7%). Of 787 patients, 451 (57.31%) were thrombolyzed, 326 (41.42%) did not receive any reperfusion therapy, and 10 patients (1.27%) underwent primary angioplasty. Younger age, window period <6 h, and lower lipoprotein (a) level were observed in patients with a recanalized infarct-related artery. Regression analysis showed window period of thrombolysis as strongest predictor (odds ratio: 1.790, 95% confidence interval: 1.144–2.802; p < 0.011) of successful reperfusion. Patients (n = 235) being thrombolyzed in a window period of <6 h, had higher rate of infarct-related artery recanalization (77%) as compared to those with ≥6 h window period (23%). In-hospital mortality was 0.38% (n = 3), whereas bleeding complication was noted only in 1 patient. Conclusions: We herewith conclude that acute short-term outcome is favorable in young ST-segment elevation myocardial infarction patients, particularly in those who had received timely thrombolytic therapy. Though tobacco consumption was a major contributor of risk in young adults, prevalence of other risk factors was low in young Western Indians.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalGlobal Heart
Volume14
Issue number1
DOIs
Publication statusPublished - 01-03-2019

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Community and Home Care
  • Cardiology and Cardiovascular Medicine

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    Shukla, A. N., Jayaram, A. A., Doshi, D., Patel, P., Shah, K., Shinde, A., Ghoniya, H., Natarajan, K., & Bansal, T. (2019). The Young Myocardial Infarction Study of the Western Indians: YOUTH Registry. Global Heart, 14(1), 27-33. https://doi.org/10.1016/j.gheart.2018.12.001