Therapeutic dimensions of ACE inhibitors- A review of literature and clinical trials

M. Prabhu, S. Palaian, A. Malhotra, P. Ravishankar, D. Bista, R. Almeida, P. Mishra

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In the 1970s, pharmacological therapy interrupting the renin-angiotensin system was considered beneficial for patients with high-renin hypertension. This gave rise to the development of ACE inhibitors. Surprisingly, the ACE inhibitors proved to be effective not only in patients with high renin hypertension, but also in many patients with normal levels of plasma renin activity. At present ACE inhibitors have a significant position in a wide range of chronic illnesses such as atherosclerosis, hypertension, myocardial infarction, diabetic complications, stroke etc. They are combined safely with drugs like angiotensin receptor blockers, calcium channel blockers and thiazides with varying degree of benefits. Though they are safe drugs, patients need monitoring for renal insufficiency, hypotension, hyperkalemia etc. The safety of these drugs in paediatrics patients is not established. It is better to avoid these drugs during pregnancy.

Original languageEnglish
Pages (from-to)296-304
Number of pages9
JournalKathmandu University Medical Journal
Volume3 no. 3
Issue number11
Publication statusPublished - 01-12-2005

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Angiotensin-Converting Enzyme Inhibitors
Renin
Clinical Trials
Hypertension
Pharmaceutical Preparations
Thiazides
Hyperkalemia
Angiotensin Receptor Antagonists
Calcium Channel Blockers
Physiologic Monitoring
Diabetes Complications
Therapeutics
Renin-Angiotensin System
Hypotension
Renal Insufficiency
Atherosclerosis
Chronic Disease
Stroke
Myocardial Infarction
Pharmacology

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Prabhu, M., Palaian, S., Malhotra, A., Ravishankar, P., Bista, D., Almeida, R., & Mishra, P. (2005). Therapeutic dimensions of ACE inhibitors- A review of literature and clinical trials. Kathmandu University Medical Journal, 3 no. 3(11), 296-304.
Prabhu, M. ; Palaian, S. ; Malhotra, A. ; Ravishankar, P. ; Bista, D. ; Almeida, R. ; Mishra, P. / Therapeutic dimensions of ACE inhibitors- A review of literature and clinical trials. In: Kathmandu University Medical Journal. 2005 ; Vol. 3 no. 3, No. 11. pp. 296-304.
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Prabhu, M, Palaian, S, Malhotra, A, Ravishankar, P, Bista, D, Almeida, R & Mishra, P 2005, 'Therapeutic dimensions of ACE inhibitors- A review of literature and clinical trials', Kathmandu University Medical Journal, vol. 3 no. 3, no. 11, pp. 296-304.

Therapeutic dimensions of ACE inhibitors- A review of literature and clinical trials. / Prabhu, M.; Palaian, S.; Malhotra, A.; Ravishankar, P.; Bista, D.; Almeida, R.; Mishra, P.

In: Kathmandu University Medical Journal, Vol. 3 no. 3, No. 11, 01.12.2005, p. 296-304.

Research output: Contribution to journalArticle

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Prabhu M, Palaian S, Malhotra A, Ravishankar P, Bista D, Almeida R et al. Therapeutic dimensions of ACE inhibitors- A review of literature and clinical trials. Kathmandu University Medical Journal. 2005 Dec 1;3 no. 3(11):296-304.