TY - JOUR
T1 - Thiol compounds as protective agents in erythrocytes under oxidative stress
AU - Udupi, Vidyavathi
AU - Rice-evans, Catherine
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The potential for the thiol-containing drugs, N-acetyl cysteine and N-mercaptopropionyl glycine, to act as antioxidants intracellularly has been studied in erythrocytes under oxidative stress. The effects have been compared with that of the glutathione peroxidase inhibitor, mercaptosuccinate. The results show differential responses of sickle and normal erythrocytes to the thiol compounds. N-acetyl cysteine is the more efficacious with no toxic effects in these systems. N-Mercaptopropionyl glycine is not only limited in its ability to demonstrate antioxidant capacity in erythrocytes but also exerts deleterious effects.
AB - The potential for the thiol-containing drugs, N-acetyl cysteine and N-mercaptopropionyl glycine, to act as antioxidants intracellularly has been studied in erythrocytes under oxidative stress. The effects have been compared with that of the glutathione peroxidase inhibitor, mercaptosuccinate. The results show differential responses of sickle and normal erythrocytes to the thiol compounds. N-acetyl cysteine is the more efficacious with no toxic effects in these systems. N-Mercaptopropionyl glycine is not only limited in its ability to demonstrate antioxidant capacity in erythrocytes but also exerts deleterious effects.
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U2 - 10.3109/10715769209049184
DO - 10.3109/10715769209049184
M3 - Article
C2 - 1505789
AN - SCOPUS:0026804692
SN - 1071-5762
VL - 16
SP - 315
EP - 323
JO - Free Radical Research
JF - Free Radical Research
IS - 5
ER -