Thyrotropin receptor antibodies in breast milk

N. Kavitha Bhat, Avinash K. Shetty, Michelle A. Reeves, Jayashree K. Rao

Research output: Contribution to journalArticle

Abstract

Transient neonatal thyroid dysfunction is known to occur as a result of transplacental passage of maternal thyrotropin receptor antibodies (TRAbs). The presence of TRAbs in breast milk and its contribution to thyroid dysfunction in breast-fed infants has not been reported. We report the cases of two infants born to mothers with Graves' disease who were breast-fed. The mothers were treated with Propylthiouracil during pregnancy and after delivery. Thyroid function tests were obtained at periodic intervals in mothers and infants. TRAb levels were measured in the breast milk and in sera of mothers and infants. One infant developed hyperthyroidism. The other infant remained euthyroid. It was found that TRAb levels in breast milk were negligible in both cases and did not appear to contribute to thyroid dysfunction in the infants.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalEndocrinologist
Volume9
Issue number1
Publication statusPublished - 11-03-1999
Externally publishedYes

Fingerprint

Thyrotropin Receptors
Human Milk
Antibodies
Mothers
Thyroid Gland
Breast
Thyroid Function Tests
Propylthiouracil
Graves Disease
Hyperthyroidism
Pregnancy
Serum

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Kavitha Bhat, N., Shetty, A. K., Reeves, M. A., & Rao, J. K. (1999). Thyrotropin receptor antibodies in breast milk. Endocrinologist, 9(1), 65-67.
Kavitha Bhat, N. ; Shetty, Avinash K. ; Reeves, Michelle A. ; Rao, Jayashree K. / Thyrotropin receptor antibodies in breast milk. In: Endocrinologist. 1999 ; Vol. 9, No. 1. pp. 65-67.
@article{29008b953b8342739ec5911dc54e6fbf,
title = "Thyrotropin receptor antibodies in breast milk",
abstract = "Transient neonatal thyroid dysfunction is known to occur as a result of transplacental passage of maternal thyrotropin receptor antibodies (TRAbs). The presence of TRAbs in breast milk and its contribution to thyroid dysfunction in breast-fed infants has not been reported. We report the cases of two infants born to mothers with Graves' disease who were breast-fed. The mothers were treated with Propylthiouracil during pregnancy and after delivery. Thyroid function tests were obtained at periodic intervals in mothers and infants. TRAb levels were measured in the breast milk and in sera of mothers and infants. One infant developed hyperthyroidism. The other infant remained euthyroid. It was found that TRAb levels in breast milk were negligible in both cases and did not appear to contribute to thyroid dysfunction in the infants.",
author = "{Kavitha Bhat}, N. and Shetty, {Avinash K.} and Reeves, {Michelle A.} and Rao, {Jayashree K.}",
year = "1999",
month = "3",
day = "11",
language = "English",
volume = "9",
pages = "65--67",
journal = "Endocrinologist",
issn = "1051-2144",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "1",

}

Kavitha Bhat, N, Shetty, AK, Reeves, MA & Rao, JK 1999, 'Thyrotropin receptor antibodies in breast milk', Endocrinologist, vol. 9, no. 1, pp. 65-67.

Thyrotropin receptor antibodies in breast milk. / Kavitha Bhat, N.; Shetty, Avinash K.; Reeves, Michelle A.; Rao, Jayashree K.

In: Endocrinologist, Vol. 9, No. 1, 11.03.1999, p. 65-67.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Thyrotropin receptor antibodies in breast milk

AU - Kavitha Bhat, N.

AU - Shetty, Avinash K.

AU - Reeves, Michelle A.

AU - Rao, Jayashree K.

PY - 1999/3/11

Y1 - 1999/3/11

N2 - Transient neonatal thyroid dysfunction is known to occur as a result of transplacental passage of maternal thyrotropin receptor antibodies (TRAbs). The presence of TRAbs in breast milk and its contribution to thyroid dysfunction in breast-fed infants has not been reported. We report the cases of two infants born to mothers with Graves' disease who were breast-fed. The mothers were treated with Propylthiouracil during pregnancy and after delivery. Thyroid function tests were obtained at periodic intervals in mothers and infants. TRAb levels were measured in the breast milk and in sera of mothers and infants. One infant developed hyperthyroidism. The other infant remained euthyroid. It was found that TRAb levels in breast milk were negligible in both cases and did not appear to contribute to thyroid dysfunction in the infants.

AB - Transient neonatal thyroid dysfunction is known to occur as a result of transplacental passage of maternal thyrotropin receptor antibodies (TRAbs). The presence of TRAbs in breast milk and its contribution to thyroid dysfunction in breast-fed infants has not been reported. We report the cases of two infants born to mothers with Graves' disease who were breast-fed. The mothers were treated with Propylthiouracil during pregnancy and after delivery. Thyroid function tests were obtained at periodic intervals in mothers and infants. TRAb levels were measured in the breast milk and in sera of mothers and infants. One infant developed hyperthyroidism. The other infant remained euthyroid. It was found that TRAb levels in breast milk were negligible in both cases and did not appear to contribute to thyroid dysfunction in the infants.

UR - http://www.scopus.com/inward/record.url?scp=0033050693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033050693&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0033050693

VL - 9

SP - 65

EP - 67

JO - Endocrinologist

JF - Endocrinologist

SN - 1051-2144

IS - 1

ER -

Kavitha Bhat N, Shetty AK, Reeves MA, Rao JK. Thyrotropin receptor antibodies in breast milk. Endocrinologist. 1999 Mar 11;9(1):65-67.