Time delays in diagnosis of pulmonary tuberculosis

A systematic review of literature

Chandrashekhar T. Sreeramareddy, Kishore V. Panduru, Joris Menten, J. Van den Ende

Research output: Contribution to journalReview article

238 Citations (Scopus)

Abstract

Background: Delay in diagnosis of pulmonary tuberculosis results in increasing severity, mortality and transmission. Various investigators have reported about delays in diagnosis of tuberculosis. We aimed at summarizing the data on these delays in diagnosis of tuberculosis. Methods: A systematic review of literature was carried out. Literature search was done in Medline and EMBASE from 1990 to 2008. We used the following search terms: delay, tuberculosis, diagnosis, and help-seeking/ health-seeking behavior without language restrictions. In addition, indices of four major tuberculosis journals were hand-searched. Subject experts in tuberculosis and authors of primary studies were contacted. Reference lists, review articles and text book chapters were also searched. All the studies were assessed for methodological quality. Only studies carried out on smear/culture-positive tuberculosis patients and reporting about total, patient and health-care system delays were included. Results: A total of 419 potential studies were identified by the search. Fifty two studies qualified for the review. The reported ranges of average (median or mean) total delay, patient delay, health system delay were 25-185 days, 4.9-162 days and 2-87 days respectively for both low and high income countries. Average patient delay was similar to health system delay (28.7 versus 25 days). Both patient delay and health system delay in low income countries (31.7 days and 28.5 days) were similar to those reported in high income countries (25.8 days and 21.5 days). Conclusion: The results of this review suggest that there is a need for revising case-finding strategies. The reported high treatment success rate of directly observed treatment may be supplemented by measures to shorten the delay in diagnosis. This may result in reduction of infectious cases and better tuberculosis control.

Original languageEnglish
Article number91
JournalBMC Infectious Diseases
Volume9
DOIs
Publication statusPublished - 11-06-2009
Externally publishedYes

Fingerprint

Pulmonary Tuberculosis
Tuberculosis
Health
Patient Care
Language
Research Personnel
Delivery of Health Care
Mortality
Therapeutics

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

Cite this

Sreeramareddy, Chandrashekhar T. ; Panduru, Kishore V. ; Menten, Joris ; Van den Ende, J. / Time delays in diagnosis of pulmonary tuberculosis : A systematic review of literature. In: BMC Infectious Diseases. 2009 ; Vol. 9.
@article{7727c40b6a304710acf00e10c3e1fae5,
title = "Time delays in diagnosis of pulmonary tuberculosis: A systematic review of literature",
abstract = "Background: Delay in diagnosis of pulmonary tuberculosis results in increasing severity, mortality and transmission. Various investigators have reported about delays in diagnosis of tuberculosis. We aimed at summarizing the data on these delays in diagnosis of tuberculosis. Methods: A systematic review of literature was carried out. Literature search was done in Medline and EMBASE from 1990 to 2008. We used the following search terms: delay, tuberculosis, diagnosis, and help-seeking/ health-seeking behavior without language restrictions. In addition, indices of four major tuberculosis journals were hand-searched. Subject experts in tuberculosis and authors of primary studies were contacted. Reference lists, review articles and text book chapters were also searched. All the studies were assessed for methodological quality. Only studies carried out on smear/culture-positive tuberculosis patients and reporting about total, patient and health-care system delays were included. Results: A total of 419 potential studies were identified by the search. Fifty two studies qualified for the review. The reported ranges of average (median or mean) total delay, patient delay, health system delay were 25-185 days, 4.9-162 days and 2-87 days respectively for both low and high income countries. Average patient delay was similar to health system delay (28.7 versus 25 days). Both patient delay and health system delay in low income countries (31.7 days and 28.5 days) were similar to those reported in high income countries (25.8 days and 21.5 days). Conclusion: The results of this review suggest that there is a need for revising case-finding strategies. The reported high treatment success rate of directly observed treatment may be supplemented by measures to shorten the delay in diagnosis. This may result in reduction of infectious cases and better tuberculosis control.",
author = "Sreeramareddy, {Chandrashekhar T.} and Panduru, {Kishore V.} and Joris Menten and {Van den Ende}, J.",
year = "2009",
month = "6",
day = "11",
doi = "10.1186/1471-2334-9-91",
language = "English",
volume = "9",
journal = "BMC Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central",

}

Time delays in diagnosis of pulmonary tuberculosis : A systematic review of literature. / Sreeramareddy, Chandrashekhar T.; Panduru, Kishore V.; Menten, Joris; Van den Ende, J.

In: BMC Infectious Diseases, Vol. 9, 91, 11.06.2009.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Time delays in diagnosis of pulmonary tuberculosis

T2 - A systematic review of literature

AU - Sreeramareddy, Chandrashekhar T.

AU - Panduru, Kishore V.

AU - Menten, Joris

AU - Van den Ende, J.

PY - 2009/6/11

Y1 - 2009/6/11

N2 - Background: Delay in diagnosis of pulmonary tuberculosis results in increasing severity, mortality and transmission. Various investigators have reported about delays in diagnosis of tuberculosis. We aimed at summarizing the data on these delays in diagnosis of tuberculosis. Methods: A systematic review of literature was carried out. Literature search was done in Medline and EMBASE from 1990 to 2008. We used the following search terms: delay, tuberculosis, diagnosis, and help-seeking/ health-seeking behavior without language restrictions. In addition, indices of four major tuberculosis journals were hand-searched. Subject experts in tuberculosis and authors of primary studies were contacted. Reference lists, review articles and text book chapters were also searched. All the studies were assessed for methodological quality. Only studies carried out on smear/culture-positive tuberculosis patients and reporting about total, patient and health-care system delays were included. Results: A total of 419 potential studies were identified by the search. Fifty two studies qualified for the review. The reported ranges of average (median or mean) total delay, patient delay, health system delay were 25-185 days, 4.9-162 days and 2-87 days respectively for both low and high income countries. Average patient delay was similar to health system delay (28.7 versus 25 days). Both patient delay and health system delay in low income countries (31.7 days and 28.5 days) were similar to those reported in high income countries (25.8 days and 21.5 days). Conclusion: The results of this review suggest that there is a need for revising case-finding strategies. The reported high treatment success rate of directly observed treatment may be supplemented by measures to shorten the delay in diagnosis. This may result in reduction of infectious cases and better tuberculosis control.

AB - Background: Delay in diagnosis of pulmonary tuberculosis results in increasing severity, mortality and transmission. Various investigators have reported about delays in diagnosis of tuberculosis. We aimed at summarizing the data on these delays in diagnosis of tuberculosis. Methods: A systematic review of literature was carried out. Literature search was done in Medline and EMBASE from 1990 to 2008. We used the following search terms: delay, tuberculosis, diagnosis, and help-seeking/ health-seeking behavior without language restrictions. In addition, indices of four major tuberculosis journals were hand-searched. Subject experts in tuberculosis and authors of primary studies were contacted. Reference lists, review articles and text book chapters were also searched. All the studies were assessed for methodological quality. Only studies carried out on smear/culture-positive tuberculosis patients and reporting about total, patient and health-care system delays were included. Results: A total of 419 potential studies were identified by the search. Fifty two studies qualified for the review. The reported ranges of average (median or mean) total delay, patient delay, health system delay were 25-185 days, 4.9-162 days and 2-87 days respectively for both low and high income countries. Average patient delay was similar to health system delay (28.7 versus 25 days). Both patient delay and health system delay in low income countries (31.7 days and 28.5 days) were similar to those reported in high income countries (25.8 days and 21.5 days). Conclusion: The results of this review suggest that there is a need for revising case-finding strategies. The reported high treatment success rate of directly observed treatment may be supplemented by measures to shorten the delay in diagnosis. This may result in reduction of infectious cases and better tuberculosis control.

UR - http://www.scopus.com/inward/record.url?scp=67649908265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649908265&partnerID=8YFLogxK

U2 - 10.1186/1471-2334-9-91

DO - 10.1186/1471-2334-9-91

M3 - Review article

VL - 9

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

M1 - 91

ER -