Time-level relationship between indicators of oxidative stress and Glasgow Coma Scale scores of severe head injury patients

Chandrika Nayak, Dinesh Nayak, Annaswamy Raja, Anjali Rao

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Oxidative stress is said to strongly influence the neurological recovery of patients following a severe head injury. Estimation of the markers of oxidative stress in the blood of such patients can hence aid in predicting the prognosis of head injury. Methods: Erythrocyte thiobarbituric acid-reactive substances (TBARS) and plasma ceruloplasmin (CP) levels were estimated in 24 severe head-injury patients on days 1, 7 and 21 of the post-traumatic period and compared with levels in 25 healthy age-and sex-matched controls. These parameters reflecting oxidative stress status were related to the Glasgow Coma Scale (GCS) scores of patients noted at the same time points of the study period. Results: Lipid peroxidation as indicated by increased levels of erythrocyte TBARS remained significantly elevated in severe head injury patients compared to controls on day 1 (p < 0.001), day 7 (p < 0.001) and 21 (p < 0.001) of the post-traumatic period. Plasma CP levels remained significantly elevated (p < 0.001) at these three time points compared to controls. The significant decrease in lipid peroxidation products (p < 0.01) and significant increase in CP levels (p < 0.001) on day 21 compared to day 1 in head injury patients correlated well with the significant improvement in GCS scores of patients on day 21 compared to day 1 (p < 0.05). Conclusion: The above results could account for the adaptation of the study patients to severe oxidative stress, as evidenced by their clinical recovery trend during the study period.

Original languageEnglish
Pages (from-to)460-463
Number of pages4
JournalClinical Chemistry and Laboratory Medicine
Volume44
Issue number4
DOIs
Publication statusPublished - 01-04-2006

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Glasgow Coma Scale
Oxidative stress
Craniocerebral Trauma
Ceruloplasmin
Oxidative Stress
Thiobarbituric Acid Reactive Substances
Lipids
Plasmas
Recovery
Lipid Peroxidation
Blood
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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abstract = "Background: Oxidative stress is said to strongly influence the neurological recovery of patients following a severe head injury. Estimation of the markers of oxidative stress in the blood of such patients can hence aid in predicting the prognosis of head injury. Methods: Erythrocyte thiobarbituric acid-reactive substances (TBARS) and plasma ceruloplasmin (CP) levels were estimated in 24 severe head-injury patients on days 1, 7 and 21 of the post-traumatic period and compared with levels in 25 healthy age-and sex-matched controls. These parameters reflecting oxidative stress status were related to the Glasgow Coma Scale (GCS) scores of patients noted at the same time points of the study period. Results: Lipid peroxidation as indicated by increased levels of erythrocyte TBARS remained significantly elevated in severe head injury patients compared to controls on day 1 (p < 0.001), day 7 (p < 0.001) and 21 (p < 0.001) of the post-traumatic period. Plasma CP levels remained significantly elevated (p < 0.001) at these three time points compared to controls. The significant decrease in lipid peroxidation products (p < 0.01) and significant increase in CP levels (p < 0.001) on day 21 compared to day 1 in head injury patients correlated well with the significant improvement in GCS scores of patients on day 21 compared to day 1 (p < 0.05). Conclusion: The above results could account for the adaptation of the study patients to severe oxidative stress, as evidenced by their clinical recovery trend during the study period.",
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Time-level relationship between indicators of oxidative stress and Glasgow Coma Scale scores of severe head injury patients. / Nayak, Chandrika; Nayak, Dinesh; Raja, Annaswamy; Rao, Anjali.

In: Clinical Chemistry and Laboratory Medicine, Vol. 44, No. 4, 01.04.2006, p. 460-463.

Research output: Contribution to journalArticle

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AU - Nayak, Dinesh

AU - Raja, Annaswamy

AU - Rao, Anjali

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N2 - Background: Oxidative stress is said to strongly influence the neurological recovery of patients following a severe head injury. Estimation of the markers of oxidative stress in the blood of such patients can hence aid in predicting the prognosis of head injury. Methods: Erythrocyte thiobarbituric acid-reactive substances (TBARS) and plasma ceruloplasmin (CP) levels were estimated in 24 severe head-injury patients on days 1, 7 and 21 of the post-traumatic period and compared with levels in 25 healthy age-and sex-matched controls. These parameters reflecting oxidative stress status were related to the Glasgow Coma Scale (GCS) scores of patients noted at the same time points of the study period. Results: Lipid peroxidation as indicated by increased levels of erythrocyte TBARS remained significantly elevated in severe head injury patients compared to controls on day 1 (p < 0.001), day 7 (p < 0.001) and 21 (p < 0.001) of the post-traumatic period. Plasma CP levels remained significantly elevated (p < 0.001) at these three time points compared to controls. The significant decrease in lipid peroxidation products (p < 0.01) and significant increase in CP levels (p < 0.001) on day 21 compared to day 1 in head injury patients correlated well with the significant improvement in GCS scores of patients on day 21 compared to day 1 (p < 0.05). Conclusion: The above results could account for the adaptation of the study patients to severe oxidative stress, as evidenced by their clinical recovery trend during the study period.

AB - Background: Oxidative stress is said to strongly influence the neurological recovery of patients following a severe head injury. Estimation of the markers of oxidative stress in the blood of such patients can hence aid in predicting the prognosis of head injury. Methods: Erythrocyte thiobarbituric acid-reactive substances (TBARS) and plasma ceruloplasmin (CP) levels were estimated in 24 severe head-injury patients on days 1, 7 and 21 of the post-traumatic period and compared with levels in 25 healthy age-and sex-matched controls. These parameters reflecting oxidative stress status were related to the Glasgow Coma Scale (GCS) scores of patients noted at the same time points of the study period. Results: Lipid peroxidation as indicated by increased levels of erythrocyte TBARS remained significantly elevated in severe head injury patients compared to controls on day 1 (p < 0.001), day 7 (p < 0.001) and 21 (p < 0.001) of the post-traumatic period. Plasma CP levels remained significantly elevated (p < 0.001) at these three time points compared to controls. The significant decrease in lipid peroxidation products (p < 0.01) and significant increase in CP levels (p < 0.001) on day 21 compared to day 1 in head injury patients correlated well with the significant improvement in GCS scores of patients on day 21 compared to day 1 (p < 0.05). Conclusion: The above results could account for the adaptation of the study patients to severe oxidative stress, as evidenced by their clinical recovery trend during the study period.

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