Tinidazole concentration in human gingival crevicular fluid after insertion of biodegradable dental implants

R. Nagaraju, N. Udupa, B. R.R. Varma

Research output: Contribution to journalArticle

Abstract

Dental implants of tinidazole were formulated using Poly (ε-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out to evaluate the usefulness in periodontal therapy. Gingival crevicular fluid concentration of the drug was found to be 4.9±13.2 μg per mg of gingival fluid which was higher than the minimum inhibitory concentration for many of the periodontal pathogens through out the period of study (40 days). Low drug concentration was found in saliva which is desirable. High concentration of drug in saliva may supress the normal commencal flora of the oral cavity and may also pose a risk of over growth of opportunistic organisms causing several adverse effects. The implants prepared were capable of releasing tinidazole and maintain effective concentration in gingival crevicular fluid for an adequate duration of time to inhibit the growth of various periodontopathic organisms which confirms the clinical efficacy of the implants prepared.

Original languageEnglish
Pages (from-to)540-542
Number of pages3
JournalIndian Journal of Pharmaceutical Sciences
Volume65
Issue number5
Publication statusPublished - 2003

Fingerprint

Absorbable Implants
Tinidazole
Gingival Crevicular Fluid
Dental Implants
Saliva
Pharmaceutical Preparations
Microbial Sensitivity Tests
Growth
Mouth
Polymers
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

@article{349abbb9353b4f86af2389888bb449d3,
title = "Tinidazole concentration in human gingival crevicular fluid after insertion of biodegradable dental implants",
abstract = "Dental implants of tinidazole were formulated using Poly (ε-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out to evaluate the usefulness in periodontal therapy. Gingival crevicular fluid concentration of the drug was found to be 4.9±13.2 μg per mg of gingival fluid which was higher than the minimum inhibitory concentration for many of the periodontal pathogens through out the period of study (40 days). Low drug concentration was found in saliva which is desirable. High concentration of drug in saliva may supress the normal commencal flora of the oral cavity and may also pose a risk of over growth of opportunistic organisms causing several adverse effects. The implants prepared were capable of releasing tinidazole and maintain effective concentration in gingival crevicular fluid for an adequate duration of time to inhibit the growth of various periodontopathic organisms which confirms the clinical efficacy of the implants prepared.",
author = "R. Nagaraju and N. Udupa and Varma, {B. R.R.}",
year = "2003",
language = "English",
volume = "65",
pages = "540--542",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "5",

}

Tinidazole concentration in human gingival crevicular fluid after insertion of biodegradable dental implants. / Nagaraju, R.; Udupa, N.; Varma, B. R.R.

In: Indian Journal of Pharmaceutical Sciences, Vol. 65, No. 5, 2003, p. 540-542.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Tinidazole concentration in human gingival crevicular fluid after insertion of biodegradable dental implants

AU - Nagaraju, R.

AU - Udupa, N.

AU - Varma, B. R.R.

PY - 2003

Y1 - 2003

N2 - Dental implants of tinidazole were formulated using Poly (ε-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out to evaluate the usefulness in periodontal therapy. Gingival crevicular fluid concentration of the drug was found to be 4.9±13.2 μg per mg of gingival fluid which was higher than the minimum inhibitory concentration for many of the periodontal pathogens through out the period of study (40 days). Low drug concentration was found in saliva which is desirable. High concentration of drug in saliva may supress the normal commencal flora of the oral cavity and may also pose a risk of over growth of opportunistic organisms causing several adverse effects. The implants prepared were capable of releasing tinidazole and maintain effective concentration in gingival crevicular fluid for an adequate duration of time to inhibit the growth of various periodontopathic organisms which confirms the clinical efficacy of the implants prepared.

AB - Dental implants of tinidazole were formulated using Poly (ε-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out to evaluate the usefulness in periodontal therapy. Gingival crevicular fluid concentration of the drug was found to be 4.9±13.2 μg per mg of gingival fluid which was higher than the minimum inhibitory concentration for many of the periodontal pathogens through out the period of study (40 days). Low drug concentration was found in saliva which is desirable. High concentration of drug in saliva may supress the normal commencal flora of the oral cavity and may also pose a risk of over growth of opportunistic organisms causing several adverse effects. The implants prepared were capable of releasing tinidazole and maintain effective concentration in gingival crevicular fluid for an adequate duration of time to inhibit the growth of various periodontopathic organisms which confirms the clinical efficacy of the implants prepared.

UR - http://www.scopus.com/inward/record.url?scp=77949843001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949843001&partnerID=8YFLogxK

M3 - Article

VL - 65

SP - 540

EP - 542

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 5

ER -