Tissue microarray - A high-throughput molecular analysis in head and neck cancer

Raghu Radhakrishnan, Monica Solomon, Kapaettu Satyamoorthy, Leslie E. Martin, Mark W. Lingen

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

With the identification of a number of novel markers having diagnostic, prognostic, and therapeutic significance, the application of tissue microarray (TMA) has become a valuable tool for validating candidate markers in cancer research. The TMA is a high-throughput technique, which allows large-scale analyses of hundreds of archival clinical tissue samples using the 'array' approach. This paper highlights briefly its robust technology, technical aspects of its construction, and the validity of the TMA results for oral pathology diagnostics by reviewing data from recent literature particularly with reference to head and neck cancer.

Original languageEnglish
Pages (from-to)166-176
Number of pages11
JournalJournal of Oral Pathology and Medicine
Volume37
Issue number3
DOIs
Publication statusPublished - 03-2008

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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