TNFR2 gene polymorphism in coronary artery disease

V. H. Sankar, K. M. Girisha, A. Gilmour, V. P. Singh, N. Sinha, S. Tewari, V. Ramesh, S. Mastana, S. Agrawal

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Recently atherosclerosis and coronary artery disease (CAD) are considered to be inflammatory diseases. The genetic polymorphism in inflammatory markers has been well studied and found to be associated with development of CAD. AIM: To study the association of biallelic polymorphism at position 196 in exon 6 of tumor necrosis factor 2 (TNFR2) gene and coronary artery disease. SETTINGS AND DESIGN: The study design was a prospective case control study conducted at a tertiary referral center mainly catering to the north Indian population. MATERIALS AND METHODS: One hundred and fifty angiographically proven patients with coronary artery disease and one hundred and fifty age matched controls were genotyped for TNFR2 gene by polymerase chain reaction followed by analysis of restriction fragment length polymorphism. STATISTICAL ANALYSIS: Genotype frequencies were compared in patients and controls by Chi-square test. Binary logistic regression analysis was used to examine the relationship between genotypes and disease, incorporating other variables into the model. RESULTS: The incidence of CAD in those with MM genotype was 65% and in those with RM genotype was 42%. Genotype frequency shows significant association of MM genotype with development of CAD (P< 0.001; odds ratio-2.585; 95% confidence interval 1.533-4.359). The association of TNFR2 genotype with CAD persisted on logistic regression analysis. CONCLUSION: MM genotype of TNFR2 gene is associated with development of CAD and RM genotype appears to be protective.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalIndian Journal of Medical Sciences
Volume59
Issue number3
Publication statusPublished - 03-2005

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Coronary Artery Disease
Tumor Necrosis Factor-alpha
Genotype
Genes
Logistic Models
Regression Analysis
Genetic Polymorphisms
Chi-Square Distribution
Tertiary Care Centers
Restriction Fragment Length Polymorphisms
Case-Control Studies
Exons
Atherosclerosis
Odds Ratio
Confidence Intervals
Polymerase Chain Reaction
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Sankar, V. H., Girisha, K. M., Gilmour, A., Singh, V. P., Sinha, N., Tewari, S., ... Agrawal, S. (2005). TNFR2 gene polymorphism in coronary artery disease. Indian Journal of Medical Sciences, 59(3), 104-108.
Sankar, V. H. ; Girisha, K. M. ; Gilmour, A. ; Singh, V. P. ; Sinha, N. ; Tewari, S. ; Ramesh, V. ; Mastana, S. ; Agrawal, S. / TNFR2 gene polymorphism in coronary artery disease. In: Indian Journal of Medical Sciences. 2005 ; Vol. 59, No. 3. pp. 104-108.
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Sankar, VH, Girisha, KM, Gilmour, A, Singh, VP, Sinha, N, Tewari, S, Ramesh, V, Mastana, S & Agrawal, S 2005, 'TNFR2 gene polymorphism in coronary artery disease', Indian Journal of Medical Sciences, vol. 59, no. 3, pp. 104-108.

TNFR2 gene polymorphism in coronary artery disease. / Sankar, V. H.; Girisha, K. M.; Gilmour, A.; Singh, V. P.; Sinha, N.; Tewari, S.; Ramesh, V.; Mastana, S.; Agrawal, S.

In: Indian Journal of Medical Sciences, Vol. 59, No. 3, 03.2005, p. 104-108.

Research output: Contribution to journalArticle

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AU - Sankar, V. H.

AU - Girisha, K. M.

AU - Gilmour, A.

AU - Singh, V. P.

AU - Sinha, N.

AU - Tewari, S.

AU - Ramesh, V.

AU - Mastana, S.

AU - Agrawal, S.

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N2 - BACKGROUND: Recently atherosclerosis and coronary artery disease (CAD) are considered to be inflammatory diseases. The genetic polymorphism in inflammatory markers has been well studied and found to be associated with development of CAD. AIM: To study the association of biallelic polymorphism at position 196 in exon 6 of tumor necrosis factor 2 (TNFR2) gene and coronary artery disease. SETTINGS AND DESIGN: The study design was a prospective case control study conducted at a tertiary referral center mainly catering to the north Indian population. MATERIALS AND METHODS: One hundred and fifty angiographically proven patients with coronary artery disease and one hundred and fifty age matched controls were genotyped for TNFR2 gene by polymerase chain reaction followed by analysis of restriction fragment length polymorphism. STATISTICAL ANALYSIS: Genotype frequencies were compared in patients and controls by Chi-square test. Binary logistic regression analysis was used to examine the relationship between genotypes and disease, incorporating other variables into the model. RESULTS: The incidence of CAD in those with MM genotype was 65% and in those with RM genotype was 42%. Genotype frequency shows significant association of MM genotype with development of CAD (P< 0.001; odds ratio-2.585; 95% confidence interval 1.533-4.359). The association of TNFR2 genotype with CAD persisted on logistic regression analysis. CONCLUSION: MM genotype of TNFR2 gene is associated with development of CAD and RM genotype appears to be protective.

AB - BACKGROUND: Recently atherosclerosis and coronary artery disease (CAD) are considered to be inflammatory diseases. The genetic polymorphism in inflammatory markers has been well studied and found to be associated with development of CAD. AIM: To study the association of biallelic polymorphism at position 196 in exon 6 of tumor necrosis factor 2 (TNFR2) gene and coronary artery disease. SETTINGS AND DESIGN: The study design was a prospective case control study conducted at a tertiary referral center mainly catering to the north Indian population. MATERIALS AND METHODS: One hundred and fifty angiographically proven patients with coronary artery disease and one hundred and fifty age matched controls were genotyped for TNFR2 gene by polymerase chain reaction followed by analysis of restriction fragment length polymorphism. STATISTICAL ANALYSIS: Genotype frequencies were compared in patients and controls by Chi-square test. Binary logistic regression analysis was used to examine the relationship between genotypes and disease, incorporating other variables into the model. RESULTS: The incidence of CAD in those with MM genotype was 65% and in those with RM genotype was 42%. Genotype frequency shows significant association of MM genotype with development of CAD (P< 0.001; odds ratio-2.585; 95% confidence interval 1.533-4.359). The association of TNFR2 genotype with CAD persisted on logistic regression analysis. CONCLUSION: MM genotype of TNFR2 gene is associated with development of CAD and RM genotype appears to be protective.

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Sankar VH, Girisha KM, Gilmour A, Singh VP, Sinha N, Tewari S et al. TNFR2 gene polymorphism in coronary artery disease. Indian Journal of Medical Sciences. 2005 Mar;59(3):104-108.