The present study evaluates the probable site of the anti-nociceptive action of Duloxetine and its interaction with Morphine and Naloxone. The anti-nociceptive activity of Duloxetine was studied using Tail flick method in the absence and presence of Naloxone in rats. Morphine 1mg/kg, Duloxetine 10mg/kg and Naloxone 1mg/kg administered intraperitoneally to study their interaction on Tail flick latency. Duloxetine 10mg/kg did not cause a significant increase in tail flick latency. A dose of 1mg/kg morphine produced a significant increase in Tail flick latency at 30mins that persisted during the entire test period. Combination of Duloxetine 10mg/kg and Morphine 1mg/kg produced an additive effect. Naloxone pretreatment did not affect the antinociception produced by Duloxetine. It is not yet known whether the analgesic action of SNRI(duloxetine) involves an interaction with opioid system similar to tricyclic antidepressants but the present study suggest opioid system does not contribute to the effect of duloxetine.
|Number of pages||8|
|Publication status||Published - 01-12-2011|
All Science Journal Classification (ASJC) codes
- Drug Discovery