Abstract
The present study was undertaken to appraise the topical effects of Jatyadi Taila [JT] on normal and dexamethasone (DEX) suppressed wound healing in albino Wistar rats. Incision and excision wounds were experimentally induced in the animals. Topical application of JT on normal incision wound caused a significant (p < 0.05) increase in wound breaking strength when compared to control and DEX treated animals. JT significantly (p < 0.05) improved tensile strength in JT+DEX treated group as compared to DEX group. A significant (p < 0.01) rise in hydroxyproline levels were exhibited in JT+DEX treatment as compared to normal and DEX control. JT reversed the DEX suppressed inflammation which was evident from the histo-pathological studies showing increased neutrophils and macrophage infiltration. Dense collagen deposition and high fibroblast counts were observed in the photomicrograph sections of JT+DEX treated group. The present study suggests the substantial potential of JT in wound management in both normal and delayed healing.
| Original language | English |
|---|---|
| Pages (from-to) | 669-677 |
| Number of pages | 9 |
| Journal | Research Journal of Pharmaceutical, Biological and Chemical Sciences |
| Volume | 7 |
| Issue number | 4 |
| Publication status | Published - 01-07-2016 |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)