Topical use of jatyadi oil in normal and dexamethasone suppressed wound healing in animal studies

Sherin Babykutty, Sumisha Jose, Rekha R. Shenoy

Research output: Contribution to journalArticle

Abstract

The present study was undertaken to appraise the topical effects of Jatyadi Taila [JT] on normal and dexamethasone (DEX) suppressed wound healing in albino Wistar rats. Incision and excision wounds were experimentally induced in the animals. Topical application of JT on normal incision wound caused a significant (p < 0.05) increase in wound breaking strength when compared to control and DEX treated animals. JT significantly (p < 0.05) improved tensile strength in JT+DEX treated group as compared to DEX group. A significant (p < 0.01) rise in hydroxyproline levels were exhibited in JT+DEX treatment as compared to normal and DEX control. JT reversed the DEX suppressed inflammation which was evident from the histo-pathological studies showing increased neutrophils and macrophage infiltration. Dense collagen deposition and high fibroblast counts were observed in the photomicrograph sections of JT+DEX treated group. The present study suggests the substantial potential of JT in wound management in both normal and delayed healing.

Original languageEnglish
Pages (from-to)669-677
Number of pages9
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume7
Issue number4
Publication statusPublished - 01-07-2016

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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