Topiramate induced acute secondary angle closure glaucoma and myopic shift: A case review

Shobha G. Pai, Ashwin Pai, Gurudutt Kamath, Sheila R. Pai, Nishant Rathi

Research output: Contribution to journalReview article

Abstract

Introduction: Acute myopia and secondary acute angle-closure glaucoma are serious adverse effects of topiramate use, both of which are reversible with immediate discontinuation of the drug. Topiramate is an oral sulfamate medication used primarily for epilepsy and migraine1. Other uses of topiramate include use in management of peripheral neuropathies and radiculopathies, idiopathic intracranial hypertension, adjunctive therapy in alcohol dependence and nicotine cessation2 Case presentation: A 40 year old man, on oral topiramate for alcohol dependence, presented with complaints of severe pain, redness and sudden loss of vision in both eyes since two days. Best corrected visual acuity was 20/20 in both eyes with minus three diopters sphere. A diagnosis of secondary angle closure glaucoma with myopic shift was made. Conclusion: Topiramate was discontinued immediately and anti glaucoma therapy initiated along with topical steroids. Unaided visual acuity returned to 20/20 in both eyes with normal anterior segment and intraocular pressure within one week of treatment.

Original languageEnglish
JournalInternet Journal of Pharmacology
Volume9
Issue number2
Publication statusPublished - 24-10-2011

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Angle Closure Glaucoma
Alcoholism
Visual Acuity
Pseudotumor Cerebri
Radiculopathy
Myopia
Peripheral Nervous System Diseases
Intraocular Pressure
Nicotine
Glaucoma
Epilepsy
Therapeutics
Steroids
topiramate
Pain
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Pai, Shobha G. ; Pai, Ashwin ; Kamath, Gurudutt ; Pai, Sheila R. ; Rathi, Nishant. / Topiramate induced acute secondary angle closure glaucoma and myopic shift : A case review. In: Internet Journal of Pharmacology. 2011 ; Vol. 9, No. 2.
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abstract = "Introduction: Acute myopia and secondary acute angle-closure glaucoma are serious adverse effects of topiramate use, both of which are reversible with immediate discontinuation of the drug. Topiramate is an oral sulfamate medication used primarily for epilepsy and migraine1. Other uses of topiramate include use in management of peripheral neuropathies and radiculopathies, idiopathic intracranial hypertension, adjunctive therapy in alcohol dependence and nicotine cessation2 Case presentation: A 40 year old man, on oral topiramate for alcohol dependence, presented with complaints of severe pain, redness and sudden loss of vision in both eyes since two days. Best corrected visual acuity was 20/20 in both eyes with minus three diopters sphere. A diagnosis of secondary angle closure glaucoma with myopic shift was made. Conclusion: Topiramate was discontinued immediately and anti glaucoma therapy initiated along with topical steroids. Unaided visual acuity returned to 20/20 in both eyes with normal anterior segment and intraocular pressure within one week of treatment.",
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Topiramate induced acute secondary angle closure glaucoma and myopic shift : A case review. / Pai, Shobha G.; Pai, Ashwin; Kamath, Gurudutt; Pai, Sheila R.; Rathi, Nishant.

In: Internet Journal of Pharmacology, Vol. 9, No. 2, 24.10.2011.

Research output: Contribution to journalReview article

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T1 - Topiramate induced acute secondary angle closure glaucoma and myopic shift

T2 - A case review

AU - Pai, Shobha G.

AU - Pai, Ashwin

AU - Kamath, Gurudutt

AU - Pai, Sheila R.

AU - Rathi, Nishant

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Y1 - 2011/10/24

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AB - Introduction: Acute myopia and secondary acute angle-closure glaucoma are serious adverse effects of topiramate use, both of which are reversible with immediate discontinuation of the drug. Topiramate is an oral sulfamate medication used primarily for epilepsy and migraine1. Other uses of topiramate include use in management of peripheral neuropathies and radiculopathies, idiopathic intracranial hypertension, adjunctive therapy in alcohol dependence and nicotine cessation2 Case presentation: A 40 year old man, on oral topiramate for alcohol dependence, presented with complaints of severe pain, redness and sudden loss of vision in both eyes since two days. Best corrected visual acuity was 20/20 in both eyes with minus three diopters sphere. A diagnosis of secondary angle closure glaucoma with myopic shift was made. Conclusion: Topiramate was discontinued immediately and anti glaucoma therapy initiated along with topical steroids. Unaided visual acuity returned to 20/20 in both eyes with normal anterior segment and intraocular pressure within one week of treatment.

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