Total antioxidant activity in Parkinson's disease

Usha Adiga, J. D'Souza, R. Kousalya, Gayathri M. Rao, M. Nandini, V. D'Souza

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Parkinson's disease (PD) is one of the major progressive neurological disorders, characterized by the loss of dopaminergic neurons in pars compacta of the substantia nigra. The causes for this is the interactions between external toxins (which arise from environmental, dietary and life style factors) and internal toxins arising from normal metabolism, genetic and epigenetic (mitochondria, membranes and proteins) components. Oxidative stress is one of the intermediary risk factors that could initiate and promote degeneration of neurons. Even though oxidative stress in brain is an important factor in the neuropathology of PD, yet the role of systemic oxidative stress is inconclusive. In the present study, we estimated the total antioxidant activity (AOA) and albumin levels in twenty PD patients who were on levodopa, and in age matched twenty-five normal controls. We observed a significant reduction in total antioxidant activity in PD patients with a mean value of 0.93 ± 0.17 mmol/1 as compared to 1.06 ± 0.16 mmol/1 in controls (P < 0.001). Albumin levels were also significantly reduced in PD patients, with a mean of 2.52 ± 0.29 g/dl as compared to 3.0 ± 0.54 g/dl in controls (P < 0.001). It could be concluded from our study that the diminution in total antioxidant activity could be due to the reduction of radical trapping capacity of naturally occurring antioxidant albumin, which in turn could be due to reduced dietary supplementation or defective absorption of amino acids. Supplementation of multiple antioxidants may slow down the progression of the disease.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalBiomedical Research
Volume17
Issue number2
Publication statusPublished - 01-05-2006

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Parkinson Disease
Antioxidants
Oxidative stress
Albumins
Oxidative Stress
Neurons
Nerve Degeneration
Dopaminergic Neurons
Levodopa
Dietary Supplements
Nervous System Diseases
Mitochondria
Epigenomics
Disease Progression
Life Style
Membrane Proteins
Metabolism
Brain
Amino Acids

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Adiga, U., D'Souza, J., Kousalya, R., Rao, G. M., Nandini, M., & D'Souza, V. (2006). Total antioxidant activity in Parkinson's disease. Biomedical Research, 17(2), 145-147.
Adiga, Usha ; D'Souza, J. ; Kousalya, R. ; Rao, Gayathri M. ; Nandini, M. ; D'Souza, V. / Total antioxidant activity in Parkinson's disease. In: Biomedical Research. 2006 ; Vol. 17, No. 2. pp. 145-147.
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Adiga, U, D'Souza, J, Kousalya, R, Rao, GM, Nandini, M & D'Souza, V 2006, 'Total antioxidant activity in Parkinson's disease', Biomedical Research, vol. 17, no. 2, pp. 145-147.

Total antioxidant activity in Parkinson's disease. / Adiga, Usha; D'Souza, J.; Kousalya, R.; Rao, Gayathri M.; Nandini, M.; D'Souza, V.

In: Biomedical Research, Vol. 17, No. 2, 01.05.2006, p. 145-147.

Research output: Contribution to journalArticle

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Adiga U, D'Souza J, Kousalya R, Rao GM, Nandini M, D'Souza V. Total antioxidant activity in Parkinson's disease. Biomedical Research. 2006 May 1;17(2):145-147.