Total thiols and MDA levels in patients with acute myocardial infarction before and after reperfusion therapy

Suresh Babu, Jeevan K. Shetty, Mungli Prakash

Research output: Contribution to journalArticle

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Abstract

Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p<0.05) and positively with CK-MB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalOnline Journal of Health and Allied Sciences
Volume9
Issue number3
Publication statusPublished - 01-07-2010
Externally publishedYes

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Malondialdehyde
Sulfhydryl Compounds
Reperfusion
Myocardial Infarction
Thrombolytic Therapy
Reactive Oxygen Species
Therapeutics
Streptokinase
Fibrinolytic Agents
Reperfusion Injury
Electrocardiography
Antioxidants
Enzymes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p<0.05) and positively with CK-MB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.",
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Total thiols and MDA levels in patients with acute myocardial infarction before and after reperfusion therapy. / Babu, Suresh; Shetty, Jeevan K.; Prakash, Mungli.

In: Online Journal of Health and Allied Sciences, Vol. 9, No. 3, 01.07.2010, p. 1-4.

Research output: Contribution to journalArticle

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