Toward the integration of Omics data in epidemiological studies: still a “long and winding road”

Evangelina López de Maturana, Sílvia Pineda, Angela Brand, Kristel Van Steen, Núria Malats

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Primary and secondary prevention can highly benefit a personalized medicine approach through the accurate discrimination of individuals at high risk of developing a specific disease from those at moderate and low risk. To this end precise risk prediction models need to be built. This endeavor requires a precise characterization of the individual exposome, genome, and phenome. Massive molecular omics data representing the different layers of the biological processes of the host and the nonhost will enable to build more accurate risk prediction models. Epidemiologists aim to integrate omics data along with important information coming from other sources (questionnaires, candidate markers) that has been proved to be relevant in the discrimination risk assessment of complex diseases. However, the integrative models in large-scale epidemiologic research are still in their infancy and they face numerous challenges, some of them at the analytical stage. So far, there are a small number of studies that have integrated more than two omics data sets, and the inclusion of non-omics data in the same models is still missing in most of studies. In this contribution, we aim at approaching the omics and non-omics data integration from the epidemiology scope by considering the “massive” inclusion of variables in the risk assessment and predictive models. We also provide already available examples of integrative contributions in the field, propose analytical strategies that allow considering both omics and non-omics data in the models, and finally review the challenges imbedding this type of research.

Original languageEnglish
Pages (from-to)558-569
Number of pages12
JournalGenetic Epidemiology
Volume40
Issue number7
DOIs
Publication statusPublished - 01-11-2016

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Epidemiologic Studies
Biological Phenomena
Precision Medicine
Primary Prevention
Secondary Prevention
Research
Epidemiology
Genome

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Genetics(clinical)

Cite this

López de Maturana, Evangelina ; Pineda, Sílvia ; Brand, Angela ; Van Steen, Kristel ; Malats, Núria. / Toward the integration of Omics data in epidemiological studies : still a “long and winding road”. In: Genetic Epidemiology. 2016 ; Vol. 40, No. 7. pp. 558-569.
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Toward the integration of Omics data in epidemiological studies : still a “long and winding road”. / López de Maturana, Evangelina; Pineda, Sílvia; Brand, Angela; Van Steen, Kristel; Malats, Núria.

In: Genetic Epidemiology, Vol. 40, No. 7, 01.11.2016, p. 558-569.

Research output: Contribution to journalArticle

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