Toxicity and antitumor activity of niosomal bleomycin in tumor bearing mice

R. A. Raja Naresh, N. Udupa, P. Uma Devi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Niosomal encapsulation of bleomycin enhanced the antitumor activity against Ehrlich ascites and sarcoma-180 models. The niosomal/free drug mean survival time values of 1.28 was achieved in Ehrlich ascites infected animals. Niosomal bleomycin considerably increased the 40 days survival rate in mice. Tumor volume doubling time of S-180 tumor was also increased significantly in niosomal treated animals. Histopathological studies of lung and jejunum of niosomal bleomycin treated mice, confirmed the less toxic potential of encapsulated bleomycin. The suppression of peripheral and bone marrow WBC counts upon niosomal bleomycin treatment was not substantial.

Original languageEnglish
Pages (from-to)764-772
Number of pages9
JournalIndian Journal of Experimental Biology
Volume34
Issue number8
Publication statusPublished - 08-1996

Fingerprint

Bleomycin
Neoplasms
Ascites
Sarcoma 180
Poisons
Jejunum
Tumor Burden
Bone Marrow
indium-bleomycin
Lung
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "Niosomal encapsulation of bleomycin enhanced the antitumor activity against Ehrlich ascites and sarcoma-180 models. The niosomal/free drug mean survival time values of 1.28 was achieved in Ehrlich ascites infected animals. Niosomal bleomycin considerably increased the 40 days survival rate in mice. Tumor volume doubling time of S-180 tumor was also increased significantly in niosomal treated animals. Histopathological studies of lung and jejunum of niosomal bleomycin treated mice, confirmed the less toxic potential of encapsulated bleomycin. The suppression of peripheral and bone marrow WBC counts upon niosomal bleomycin treatment was not substantial.",
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Toxicity and antitumor activity of niosomal bleomycin in tumor bearing mice. / Raja Naresh, R. A.; Udupa, N.; Uma Devi, P.

In: Indian Journal of Experimental Biology, Vol. 34, No. 8, 08.1996, p. 764-772.

Research output: Contribution to journalArticle

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