Toxicity prediction of compounds from turmeric (Curcuma longa L)

S. Balaji, B. Chempakam

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Turmeric belongs to the ginger family Zingiberaceae. Currently, cheminformatics approaches are not employed in any of the spices to study the medicinal properties traditionally attributed to them. The aim of this study is to find the most efficacious molecule which does not have any toxic effects. In the present study, toxicity of 200 chemical compounds from turmeric were predicted (includes bacterial mutagenicity, rodent carcinogenicity and human hepatotoxicity). The study shows out of 200 compounds, 184 compounds were predicted as toxigenic, 136 compounds are mutagenic, 153 compounds are carcinogenic and 64 compounds are hepatotoxic. To cross validate our results, we have chosen the popular curcumin and found that curcumin and its derivatives may cause dose dependent hepatotoxicity. The results of these studies indicate that, in contrast to curcumin, few other compounds in turmeric which are non-mutagenic, non-carcinogenic, non-hepatotoxic, and do not have any side-effects. Hence, the cost-effective approach presented in this paper could be used to filter toxic compounds from the drug discovery lifecycle.

Original languageEnglish
Pages (from-to)2951-2959
Number of pages9
JournalFood and Chemical Toxicology
Volume48
Issue number10
DOIs
Publication statusPublished - 10-2010

Fingerprint

Curcuma
Curcuma longa
turmeric
Curcumin
curcumin
Toxicity
hepatotoxicity
Poisons
toxicity
prediction
Zingiberaceae
Ginger
Spices
carcinogenicity
Chemical compounds
medicinal properties
mutagenicity
ginger
chemical compounds
Drug Discovery

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

@article{fef3051663764be9a574b94dda8545fd,
title = "Toxicity prediction of compounds from turmeric (Curcuma longa L)",
abstract = "Turmeric belongs to the ginger family Zingiberaceae. Currently, cheminformatics approaches are not employed in any of the spices to study the medicinal properties traditionally attributed to them. The aim of this study is to find the most efficacious molecule which does not have any toxic effects. In the present study, toxicity of 200 chemical compounds from turmeric were predicted (includes bacterial mutagenicity, rodent carcinogenicity and human hepatotoxicity). The study shows out of 200 compounds, 184 compounds were predicted as toxigenic, 136 compounds are mutagenic, 153 compounds are carcinogenic and 64 compounds are hepatotoxic. To cross validate our results, we have chosen the popular curcumin and found that curcumin and its derivatives may cause dose dependent hepatotoxicity. The results of these studies indicate that, in contrast to curcumin, few other compounds in turmeric which are non-mutagenic, non-carcinogenic, non-hepatotoxic, and do not have any side-effects. Hence, the cost-effective approach presented in this paper could be used to filter toxic compounds from the drug discovery lifecycle.",
author = "S. Balaji and B. Chempakam",
year = "2010",
month = "10",
doi = "10.1016/j.fct.2010.07.032",
language = "English",
volume = "48",
pages = "2951--2959",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",
number = "10",

}

Toxicity prediction of compounds from turmeric (Curcuma longa L). / Balaji, S.; Chempakam, B.

In: Food and Chemical Toxicology, Vol. 48, No. 10, 10.2010, p. 2951-2959.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Toxicity prediction of compounds from turmeric (Curcuma longa L)

AU - Balaji, S.

AU - Chempakam, B.

PY - 2010/10

Y1 - 2010/10

N2 - Turmeric belongs to the ginger family Zingiberaceae. Currently, cheminformatics approaches are not employed in any of the spices to study the medicinal properties traditionally attributed to them. The aim of this study is to find the most efficacious molecule which does not have any toxic effects. In the present study, toxicity of 200 chemical compounds from turmeric were predicted (includes bacterial mutagenicity, rodent carcinogenicity and human hepatotoxicity). The study shows out of 200 compounds, 184 compounds were predicted as toxigenic, 136 compounds are mutagenic, 153 compounds are carcinogenic and 64 compounds are hepatotoxic. To cross validate our results, we have chosen the popular curcumin and found that curcumin and its derivatives may cause dose dependent hepatotoxicity. The results of these studies indicate that, in contrast to curcumin, few other compounds in turmeric which are non-mutagenic, non-carcinogenic, non-hepatotoxic, and do not have any side-effects. Hence, the cost-effective approach presented in this paper could be used to filter toxic compounds from the drug discovery lifecycle.

AB - Turmeric belongs to the ginger family Zingiberaceae. Currently, cheminformatics approaches are not employed in any of the spices to study the medicinal properties traditionally attributed to them. The aim of this study is to find the most efficacious molecule which does not have any toxic effects. In the present study, toxicity of 200 chemical compounds from turmeric were predicted (includes bacterial mutagenicity, rodent carcinogenicity and human hepatotoxicity). The study shows out of 200 compounds, 184 compounds were predicted as toxigenic, 136 compounds are mutagenic, 153 compounds are carcinogenic and 64 compounds are hepatotoxic. To cross validate our results, we have chosen the popular curcumin and found that curcumin and its derivatives may cause dose dependent hepatotoxicity. The results of these studies indicate that, in contrast to curcumin, few other compounds in turmeric which are non-mutagenic, non-carcinogenic, non-hepatotoxic, and do not have any side-effects. Hence, the cost-effective approach presented in this paper could be used to filter toxic compounds from the drug discovery lifecycle.

UR - http://www.scopus.com/inward/record.url?scp=77956341395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956341395&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2010.07.032

DO - 10.1016/j.fct.2010.07.032

M3 - Article

VL - 48

SP - 2951

EP - 2959

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

IS - 10

ER -