Transient myeloproliferative disorder and eosinophilic pericardial effusion in a down syndrome neonate

Rathika D. Shenoy, Kamalakshi G. Bhat, Nutan Kamath, Yusuf Kumble

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

□ Transient myeloproliferative disorder seen in neonates with Down syndrome is often thought to have a benign course. The authors describe the clinical and laboratory profile of a neonate with Down phenotype and transient myeloproliferative disorder with pericardial effusion as co-morbidity. Pericardial fluid analysis showed eosinophils. Pericardial effusion resolved with prednisolone therapy. Regression in hepatosplenomegaly with clearance of blasts was seen by third week of illness. The clinical course suggested a benign infiltration of the pericardium. Presence of eosinophils supports the differentiating capability of the blast cells in transient myeloproliferative disorders.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalPediatric Hematology and Oncology
Volume25
Issue number2
DOIs
Publication statusPublished - 01-03-2008

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Myeloproliferative Disorders
Pericardial Effusion
Down Syndrome
Eosinophils
Pericardium
Prednisolone
Morbidity
Phenotype
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

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Transient myeloproliferative disorder and eosinophilic pericardial effusion in a down syndrome neonate. / Shenoy, Rathika D.; Bhat, Kamalakshi G.; Kamath, Nutan; Kumble, Yusuf.

In: Pediatric Hematology and Oncology, Vol. 25, No. 2, 01.03.2008, p. 123-129.

Research output: Contribution to journalArticle

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