Transjugular liver biopsy in severe alcoholic hepatitis

Shiran Shetty, L. Venkatakrishnan, J. Krishanveni, Shantha Kumari

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Alcoholic hepatitis and cirrhosis although part of spectrum of alcoholic liver disease can have overlapping features, and differentiating them using clinical, biochemical, and imaging features is not always possible. Standard therapy for each differs, and steroid therapy while beneficial in alcoholic hepatitis may be detrimental in cirrhosis due to high infectious complications. We analyzed our experience with liver biopsy in patients with severe alcoholic hepatitis. Methods: Male patients in the age group of 25–65 years who were clinically diagnosed with severe alcoholic hepatitis (DF > 32) were retrospectively analyzed and included in this study. All of them had undergone transjugular liver biopsy within the first 7 days of hospitalization. Results: Thirty patients were included. Most were in the 35–55 age group. Jaundice was present in all patients with fever and tender hepatomegaly also being common. On histopathological evaluation, 33.3% (n = 10) suspected clinically to have alcoholic hepatitis had underlying cirrhosis. Conclusion: Cirrhosis is found in one third of patients with severe alcoholic hepatitis. This may alter our approach to management of this condition.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalIndian Journal of Gastroenterology
Volume36
Issue number1
DOIs
Publication statusPublished - 01-01-2017

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Alcoholic Hepatitis
Biopsy
Liver
Fibrosis
Age Groups
Alcoholic Liver Cirrhosis
Alcoholic Liver Diseases
Hepatomegaly
Jaundice
Hospitalization
Fever
Steroids
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Shetty, Shiran ; Venkatakrishnan, L. ; Krishanveni, J. ; Kumari, Shantha. / Transjugular liver biopsy in severe alcoholic hepatitis. In: Indian Journal of Gastroenterology. 2017 ; Vol. 36, No. 1. pp. 23-26.
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Transjugular liver biopsy in severe alcoholic hepatitis. / Shetty, Shiran; Venkatakrishnan, L.; Krishanveni, J.; Kumari, Shantha.

In: Indian Journal of Gastroenterology, Vol. 36, No. 1, 01.01.2017, p. 23-26.

Research output: Contribution to journalArticle

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AB - Background: Alcoholic hepatitis and cirrhosis although part of spectrum of alcoholic liver disease can have overlapping features, and differentiating them using clinical, biochemical, and imaging features is not always possible. Standard therapy for each differs, and steroid therapy while beneficial in alcoholic hepatitis may be detrimental in cirrhosis due to high infectious complications. We analyzed our experience with liver biopsy in patients with severe alcoholic hepatitis. Methods: Male patients in the age group of 25–65 years who were clinically diagnosed with severe alcoholic hepatitis (DF > 32) were retrospectively analyzed and included in this study. All of them had undergone transjugular liver biopsy within the first 7 days of hospitalization. Results: Thirty patients were included. Most were in the 35–55 age group. Jaundice was present in all patients with fever and tender hepatomegaly also being common. On histopathological evaluation, 33.3% (n = 10) suspected clinically to have alcoholic hepatitis had underlying cirrhosis. Conclusion: Cirrhosis is found in one third of patients with severe alcoholic hepatitis. This may alter our approach to management of this condition.

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