Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis

Pratik N. Patel, Aatish Thennavan, Subhalakshmi Sen, Chetana Chandrashekar, Raghu Radhakrishnan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

About 20% of the world’s population uses some form of betel nut, which suggests that the incidence of oral submucous fibrosis (OSF) is higher than current estimates. OSF has the potential to undergo malignant transformation; thus, there is a need to identify relevant markers to assess its aggressiveness. We evaluated changes in COX-2, p53, and MDM2 expressions in progressive OSF. Expressions of COX-2, p53, and MDM2 increased with OSF progression. There was a strong association between COX-2 overexpression and recurrence of oral squamous cell carcinoma (P < 0.001) and a positive relation between increased MDM2 expression and failure of radiotherapy (P = 0.007). These findings suggest that COX-2 is an important marker of disease progression and that MDM2 expression is useful for treatment planning.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalJournal of oral science
Volume57
Issue number3
DOIs
Publication statusPublished - 25-03-2015

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Oral Submucous Fibrosis
Areca
Disease Progression
Squamous Cell Carcinoma
Radiotherapy
Recurrence
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

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title = "Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis",
abstract = "About 20{\%} of the world’s population uses some form of betel nut, which suggests that the incidence of oral submucous fibrosis (OSF) is higher than current estimates. OSF has the potential to undergo malignant transformation; thus, there is a need to identify relevant markers to assess its aggressiveness. We evaluated changes in COX-2, p53, and MDM2 expressions in progressive OSF. Expressions of COX-2, p53, and MDM2 increased with OSF progression. There was a strong association between COX-2 overexpression and recurrence of oral squamous cell carcinoma (P < 0.001) and a positive relation between increased MDM2 expression and failure of radiotherapy (P = 0.007). These findings suggest that COX-2 is an important marker of disease progression and that MDM2 expression is useful for treatment planning.",
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Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis. / Patel, Pratik N.; Thennavan, Aatish; Sen, Subhalakshmi; Chandrashekar, Chetana; Radhakrishnan, Raghu.

In: Journal of oral science, Vol. 57, No. 3, 25.03.2015, p. 169-176.

Research output: Contribution to journalArticle

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