Abstract
Currently, the preferred treatment for chloroquine (CQ) resistant Plasmodium falciparum (Pf) is Artemisinin combination therapy (ACT). Our aim was to assess the artemisinin based treatment outcomes in patients with Plasmodium falciparum infection. Patients with falciparum infection from a tertiary health care centre in South India were enrolled in this study. It was a non-randomised observational study. The data regarding peripheral blood smear, complete blood count, liver, renal function tests and the treatment given was documented at admission and on the day of discharge. Patients with uncomplicated falciparum malaria were most common. Artesunate and doxycycline was the most common combination used at our centre (54.6%) followed by artemether -lumefantrine. All patients had peripheral smear negative for Plasmodium falciparum parasite by the end of treatment. There was improvement in blood count,liver and renal function tests. Artemisinin based combination therapy was effective in treatment of falciparum malaria.
| Original language | English |
|---|---|
| Pages (from-to) | 1857-1863 |
| Number of pages | 7 |
| Journal | Biomedical and Pharmacology Journal |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-12-2018 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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Treatment outcome analysis of Artemisinin based therapy in Plasmodium falciparum infection : An observational study. / Priya, D. Amita; Meena Kumari, K.; Varma, Muralidhar; Mohanbabu, V. Amberkar; Adiga, Shalini; Balaji, O.; Vanishree, R.
In: Biomedical and Pharmacology Journal, Vol. 11, No. 4, 01.12.2018, p. 1857-1863.Research output: Contribution to journal › Article
TY - JOUR
T1 - Treatment outcome analysis of Artemisinin based therapy in Plasmodium falciparum infection
T2 - An observational study
AU - Priya, D. Amita
AU - Meena Kumari, K.
AU - Varma, Muralidhar
AU - Mohanbabu, V. Amberkar
AU - Adiga, Shalini
AU - Balaji, O.
AU - Vanishree, R.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Currently, the preferred treatment for chloroquine (CQ) resistant Plasmodium falciparum (Pf) is Artemisinin combination therapy (ACT). Our aim was to assess the artemisinin based treatment outcomes in patients with Plasmodium falciparum infection. Patients with falciparum infection from a tertiary health care centre in South India were enrolled in this study. It was a non-randomised observational study. The data regarding peripheral blood smear, complete blood count, liver, renal function tests and the treatment given was documented at admission and on the day of discharge. Patients with uncomplicated falciparum malaria were most common. Artesunate and doxycycline was the most common combination used at our centre (54.6%) followed by artemether -lumefantrine. All patients had peripheral smear negative for Plasmodium falciparum parasite by the end of treatment. There was improvement in blood count,liver and renal function tests. Artemisinin based combination therapy was effective in treatment of falciparum malaria.
AB - Currently, the preferred treatment for chloroquine (CQ) resistant Plasmodium falciparum (Pf) is Artemisinin combination therapy (ACT). Our aim was to assess the artemisinin based treatment outcomes in patients with Plasmodium falciparum infection. Patients with falciparum infection from a tertiary health care centre in South India were enrolled in this study. It was a non-randomised observational study. The data regarding peripheral blood smear, complete blood count, liver, renal function tests and the treatment given was documented at admission and on the day of discharge. Patients with uncomplicated falciparum malaria were most common. Artesunate and doxycycline was the most common combination used at our centre (54.6%) followed by artemether -lumefantrine. All patients had peripheral smear negative for Plasmodium falciparum parasite by the end of treatment. There was improvement in blood count,liver and renal function tests. Artemisinin based combination therapy was effective in treatment of falciparum malaria.
UR - http://www.scopus.com/inward/record.url?scp=85062988772&partnerID=8YFLogxK
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U2 - 10.13005/bpj/1558
DO - 10.13005/bpj/1558
M3 - Article
VL - 11
SP - 1857
EP - 1863
JO - Biomedical and Pharmacology Journal
JF - Biomedical and Pharmacology Journal
SN - 0974-6242
IS - 4
ER -