Triphala, an ayurvedic Rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging

Ganesh Chandra Jagetia, Krishna J. Malagi, Manjeshwar Shrinath Baliga, Ponemone Venkatesh, Rosi Reddy Veruva

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The effects of 10 mg/kg of triphala extract (TE) was studied on radiation-induced sickness and mortality in mice exposed to 7-12 Gray (Gy) of γ-irradiation. Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug double distilled water treated irradiated controls (DDW). Triphala provided protection against both gastrointestinal and hemopoetic death. However, animals of both the TE + irradiation and DDW + irradiation groups did not survive up to 30 days post-irradiation beyond 11 Gy irradiation. The LD50/30 was found to be 8.6 Gy for the DDW + irradiation group and 9.9 Gy for TE + irradiation group. The administration of triphala resulted in an increase in the radiation tolerance by 1.4 Gy, and the dose reduction factor was found to be 1.15. To understand the mechanism of action of triphala, the free radical scavenging activity of the drug was evaluated. Triphala was found to scavenge asterisk inside a circle signOH, O2asterisk inside a circle sign- 2,2′-azinobis(3-ethylbenzthiazoline-6-sulfonate) diammonium salt (ABTS)asterisk inside a circle sign+ and NOasterisk inside a circle sign radicals in a dose dependent manner.

Original languageEnglish
Pages (from-to)971-978
Number of pages8
JournalJournal of Alternative and Complementary Medicine
Volume10
Issue number6
DOIs
Publication statusPublished - 01-12-2004
Externally publishedYes

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Free Radicals
Radiation
Pharmaceutical Preparations
Radiation Injuries
Mortality
triphala
Radiation Tolerance
Lethal Dose 50
Salts
Water

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

Cite this

Jagetia, Ganesh Chandra ; Malagi, Krishna J. ; Baliga, Manjeshwar Shrinath ; Venkatesh, Ponemone ; Veruva, Rosi Reddy. / Triphala, an ayurvedic Rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging. In: Journal of Alternative and Complementary Medicine. 2004 ; Vol. 10, No. 6. pp. 971-978.
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Triphala, an ayurvedic Rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging. / Jagetia, Ganesh Chandra; Malagi, Krishna J.; Baliga, Manjeshwar Shrinath; Venkatesh, Ponemone; Veruva, Rosi Reddy.

In: Journal of Alternative and Complementary Medicine, Vol. 10, No. 6, 01.12.2004, p. 971-978.

Research output: Contribution to journalArticle

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