Twin to twin transfusion syndrome

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Twin to twin transfusion syndrome (TTTS) is a specific condition complicating 10-15% of monochorionic multiple pregnancy. Intertwin vascular anastomoses and transfusion is a normal event. Syndrome develops when blood flow is unbalanced. Recent studies suggest a paucity of bi-directional superficial anastomoses failing to compensate for hemodynamic imbalance resulting from unidirectional transfusion along deeper arterio-venous anastomoses. TTTS is associated with high rates of perinatal mortality. Acute and chronic forms exist and severity varies. The donor twin is often smaller, hypovolemic, anemic and develops congestive heart failure. The recipient is usually heavier and polycythemic. Antenatally, second trimester ultrasound usually detects the condition. Serial amnioreduction is the recommended therapy. Postnatally, intertwin haemoglobin and birth weight differences along with pallor in one twin and plethora in the other are helpful in making a diagnosis. Medical care of twins after birth is directed towards problem related to anemia, polycythemia and hydrops. Review of the syndrome is presented with an illustrative case.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalKathmandu University Medical Journal
Volume8
Issue number29
Publication statusPublished - 01-01-2010

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Fetofetal Transfusion
Pallor
Multiple Pregnancy
Polycythemia
Hypovolemia
Perinatal Mortality
Second Pregnancy Trimester
Birth Weight
Blood Vessels
Anemia
Edema
Hemoglobins
Heart Failure
Hemodynamics
Parturition
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Twin to twin transfusion syndrome (TTTS) is a specific condition complicating 10-15{\%} of monochorionic multiple pregnancy. Intertwin vascular anastomoses and transfusion is a normal event. Syndrome develops when blood flow is unbalanced. Recent studies suggest a paucity of bi-directional superficial anastomoses failing to compensate for hemodynamic imbalance resulting from unidirectional transfusion along deeper arterio-venous anastomoses. TTTS is associated with high rates of perinatal mortality. Acute and chronic forms exist and severity varies. The donor twin is often smaller, hypovolemic, anemic and develops congestive heart failure. The recipient is usually heavier and polycythemic. Antenatally, second trimester ultrasound usually detects the condition. Serial amnioreduction is the recommended therapy. Postnatally, intertwin haemoglobin and birth weight differences along with pallor in one twin and plethora in the other are helpful in making a diagnosis. Medical care of twins after birth is directed towards problem related to anemia, polycythemia and hydrops. Review of the syndrome is presented with an illustrative case.",
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Twin to twin transfusion syndrome. / Bhat, R.

In: Kathmandu University Medical Journal, Vol. 8, No. 29, 01.01.2010, p. 87-90.

Research output: Contribution to journalArticle

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