Two dimensional carbon based nanocomposites as multimodal therapeutic and diagnostic platform

A biomedical and toxicological perspective

Namdev Dhas, Khushali Parekh, Abhijeet Pandey, Ritu Kudarha, Srinivas Mutalik, T. Mehta

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Graphene based nanocomposites have revolutionized cancer treatment, diagnosis and imaging owing to its good compatibility, elegant flexibility, high surface area, low mass density along with excellent combined additive effect of graphene with other nanomaterials. This review inculcates the type of graphene based nanocomposites and their fabrication techniques to improve its properties as photothermal and theranostic platform. With decades’ efforts, many significant breakthroughs in the method of synthesis and characterization in addition to various functionalization options of graphene based nanocomposite have paved a solid foundation for their potential applications in the cancer therapy. This work intends to provide a thorough, up-to-date holistic discussion on correlation of breakthroughs with their biomedical applications and illustrate how to utilize these breakthroughs to address long-standing challenges in the clinical translation of nanomedicines. This review also emphasizes on graphene based nanocomposites based toxicity concerns pertaining to delivery platforms.

Original languageEnglish
Pages (from-to)130-161
Number of pages32
JournalJournal of Controlled Release
Volume308
DOIs
Publication statusPublished - 28-08-2019

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Nanocomposites
Graphite
Toxicology
Carbon
Nanomedicine
Therapeutics
Nanostructures
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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title = "Two dimensional carbon based nanocomposites as multimodal therapeutic and diagnostic platform: A biomedical and toxicological perspective",
abstract = "Graphene based nanocomposites have revolutionized cancer treatment, diagnosis and imaging owing to its good compatibility, elegant flexibility, high surface area, low mass density along with excellent combined additive effect of graphene with other nanomaterials. This review inculcates the type of graphene based nanocomposites and their fabrication techniques to improve its properties as photothermal and theranostic platform. With decades’ efforts, many significant breakthroughs in the method of synthesis and characterization in addition to various functionalization options of graphene based nanocomposite have paved a solid foundation for their potential applications in the cancer therapy. This work intends to provide a thorough, up-to-date holistic discussion on correlation of breakthroughs with their biomedical applications and illustrate how to utilize these breakthroughs to address long-standing challenges in the clinical translation of nanomedicines. This review also emphasizes on graphene based nanocomposites based toxicity concerns pertaining to delivery platforms.",
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Two dimensional carbon based nanocomposites as multimodal therapeutic and diagnostic platform : A biomedical and toxicological perspective. / Dhas, Namdev; Parekh, Khushali; Pandey, Abhijeet; Kudarha, Ritu; Mutalik, Srinivas; Mehta, T.

In: Journal of Controlled Release, Vol. 308, 28.08.2019, p. 130-161.

Research output: Contribution to journalReview article

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T2 - A biomedical and toxicological perspective

AU - Dhas, Namdev

AU - Parekh, Khushali

AU - Pandey, Abhijeet

AU - Kudarha, Ritu

AU - Mutalik, Srinivas

AU - Mehta, T.

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AB - Graphene based nanocomposites have revolutionized cancer treatment, diagnosis and imaging owing to its good compatibility, elegant flexibility, high surface area, low mass density along with excellent combined additive effect of graphene with other nanomaterials. This review inculcates the type of graphene based nanocomposites and their fabrication techniques to improve its properties as photothermal and theranostic platform. With decades’ efforts, many significant breakthroughs in the method of synthesis and characterization in addition to various functionalization options of graphene based nanocomposite have paved a solid foundation for their potential applications in the cancer therapy. This work intends to provide a thorough, up-to-date holistic discussion on correlation of breakthroughs with their biomedical applications and illustrate how to utilize these breakthroughs to address long-standing challenges in the clinical translation of nanomedicines. This review also emphasizes on graphene based nanocomposites based toxicity concerns pertaining to delivery platforms.

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