Typhoid hepatitis in children

Avinash K. Shetty, Seema R. Mital, Abdul Husein T. Bahrainwala, Raju P. Khubchandani, Narsing B. Kumta

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Liver involvement is commonly observed in patients with typhoid fever. However, a hepatitis-like picture with fever and jaundice is unusual and infrequently reported in the paediatric literature. Our aim was to characterize the clinical picture, biochemical features, and prognosis of typhoid hepatitis. One hundred cases of typhoid fever (age 0 to 12 years), proven by positive blood cultures to Salmonella typhi, were studied with special reference to hepatic dysfunction. Of these, eight patients were found to have hepatitis during the course of their illness. All had high fever, tender hepatomegaly, elevated serum bilirubin (in the range of 2.5-5.8 mg/dl), and elevated serum alanine transaminase levels (in the range 100-620 1U/l). All the eight patients showed complete clinical and biochemical recovery in response to appropriate antibiotics. The clinical picture of typhoid hepatitis frequently mimics acute viral hepatitis. In tropical areas, the differential diagnosis of a child presenting with fever and jaundice should include typhoid hepatitis.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalJournal of Tropical Pediatrics
Volume45
Issue number5
DOIs
Publication statusPublished - 01-10-1999
Externally publishedYes

Fingerprint

Typhoid Fever
Hepatitis
Fever
Jaundice
Salmonella typhi
Hepatomegaly
Liver
Serum
Alanine Transaminase
Bilirubin
Differential Diagnosis
Pediatrics
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

Cite this

Shetty, A. K., Mital, S. R., Bahrainwala, A. H. T., Khubchandani, R. P., & Kumta, N. B. (1999). Typhoid hepatitis in children. Journal of Tropical Pediatrics, 45(5), 287-290. https://doi.org/10.1093/tropej/45.5.287
Shetty, Avinash K. ; Mital, Seema R. ; Bahrainwala, Abdul Husein T. ; Khubchandani, Raju P. ; Kumta, Narsing B. / Typhoid hepatitis in children. In: Journal of Tropical Pediatrics. 1999 ; Vol. 45, No. 5. pp. 287-290.
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Shetty, AK, Mital, SR, Bahrainwala, AHT, Khubchandani, RP & Kumta, NB 1999, 'Typhoid hepatitis in children', Journal of Tropical Pediatrics, vol. 45, no. 5, pp. 287-290. https://doi.org/10.1093/tropej/45.5.287

Typhoid hepatitis in children. / Shetty, Avinash K.; Mital, Seema R.; Bahrainwala, Abdul Husein T.; Khubchandani, Raju P.; Kumta, Narsing B.

In: Journal of Tropical Pediatrics, Vol. 45, No. 5, 01.10.1999, p. 287-290.

Research output: Contribution to journalArticle

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Shetty AK, Mital SR, Bahrainwala AHT, Khubchandani RP, Kumta NB. Typhoid hepatitis in children. Journal of Tropical Pediatrics. 1999 Oct 1;45(5):287-290. https://doi.org/10.1093/tropej/45.5.287