Unravelling the insulin-like growth factor I-mediated photoprotection of the skin

Melisa J. Andrade, Derek R. Van Lonkhuyzen, Zee Upton, Kapaettu Satyamoorthy

Research output: Contribution to journalShort survey

Abstract

Chronic exposure of human skin to solar ultraviolet radiation (UVR) induces a range of biological reactions which may directly or indirectly lead to the development of skin cancer. In order to overcome these damaging effects of UVR and to reduce photodamage, the skin's endogenous defence system functions in concert with the various exogenous photoprotectors. Growth factors, particularly insulin-like growth factor-I (IGF-I), produced within the body as a result of cellular interaction in response to UVR demonstrates photoprotective properties in human skin. This review summarises the impact of UVR-induced photolesions on human skin, discusses various endogenous as well as exogenous approaches of photoprotection described to date and explains how IGF-I mediates UVR photoprotective responses at the cellular and mitochondrial level. Further, we describe the current interventions using growth factors and propose how the knowledge of the IGF-I photoprotection signalling cascades may direct the development of improved UVR protection and remedial strategies.

Original languageEnglish
JournalCytokine and Growth Factor Reviews
DOIs
Publication statusAccepted/In press - 01-01-2019

Fingerprint

Insulin-Like Growth Factor I
Ultraviolet radiation
Skin
Radiation
Intercellular Signaling Peptides and Proteins
Radiation Protection
Radiation Effects
Skin Neoplasms
Radiation protection
Solar radiation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{7fddb227530742918d62200a92d1e464,
title = "Unravelling the insulin-like growth factor I-mediated photoprotection of the skin",
abstract = "Chronic exposure of human skin to solar ultraviolet radiation (UVR) induces a range of biological reactions which may directly or indirectly lead to the development of skin cancer. In order to overcome these damaging effects of UVR and to reduce photodamage, the skin's endogenous defence system functions in concert with the various exogenous photoprotectors. Growth factors, particularly insulin-like growth factor-I (IGF-I), produced within the body as a result of cellular interaction in response to UVR demonstrates photoprotective properties in human skin. This review summarises the impact of UVR-induced photolesions on human skin, discusses various endogenous as well as exogenous approaches of photoprotection described to date and explains how IGF-I mediates UVR photoprotective responses at the cellular and mitochondrial level. Further, we describe the current interventions using growth factors and propose how the knowledge of the IGF-I photoprotection signalling cascades may direct the development of improved UVR protection and remedial strategies.",
author = "Andrade, {Melisa J.} and {Van Lonkhuyzen}, {Derek R.} and Zee Upton and Kapaettu Satyamoorthy",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.cytogfr.2019.11.004",
language = "English",
journal = "Cytokine and Growth Factor Reviews",
issn = "1359-6101",
publisher = "Elsevier BV",

}

Unravelling the insulin-like growth factor I-mediated photoprotection of the skin. / Andrade, Melisa J.; Van Lonkhuyzen, Derek R.; Upton, Zee; Satyamoorthy, Kapaettu.

In: Cytokine and Growth Factor Reviews, 01.01.2019.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Unravelling the insulin-like growth factor I-mediated photoprotection of the skin

AU - Andrade, Melisa J.

AU - Van Lonkhuyzen, Derek R.

AU - Upton, Zee

AU - Satyamoorthy, Kapaettu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Chronic exposure of human skin to solar ultraviolet radiation (UVR) induces a range of biological reactions which may directly or indirectly lead to the development of skin cancer. In order to overcome these damaging effects of UVR and to reduce photodamage, the skin's endogenous defence system functions in concert with the various exogenous photoprotectors. Growth factors, particularly insulin-like growth factor-I (IGF-I), produced within the body as a result of cellular interaction in response to UVR demonstrates photoprotective properties in human skin. This review summarises the impact of UVR-induced photolesions on human skin, discusses various endogenous as well as exogenous approaches of photoprotection described to date and explains how IGF-I mediates UVR photoprotective responses at the cellular and mitochondrial level. Further, we describe the current interventions using growth factors and propose how the knowledge of the IGF-I photoprotection signalling cascades may direct the development of improved UVR protection and remedial strategies.

AB - Chronic exposure of human skin to solar ultraviolet radiation (UVR) induces a range of biological reactions which may directly or indirectly lead to the development of skin cancer. In order to overcome these damaging effects of UVR and to reduce photodamage, the skin's endogenous defence system functions in concert with the various exogenous photoprotectors. Growth factors, particularly insulin-like growth factor-I (IGF-I), produced within the body as a result of cellular interaction in response to UVR demonstrates photoprotective properties in human skin. This review summarises the impact of UVR-induced photolesions on human skin, discusses various endogenous as well as exogenous approaches of photoprotection described to date and explains how IGF-I mediates UVR photoprotective responses at the cellular and mitochondrial level. Further, we describe the current interventions using growth factors and propose how the knowledge of the IGF-I photoprotection signalling cascades may direct the development of improved UVR protection and remedial strategies.

UR - http://www.scopus.com/inward/record.url?scp=85076567885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076567885&partnerID=8YFLogxK

U2 - 10.1016/j.cytogfr.2019.11.004

DO - 10.1016/j.cytogfr.2019.11.004

M3 - Short survey

C2 - 31767341

AN - SCOPUS:85076567885

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

SN - 1359-6101

ER -