Unresectable squamous cell carcinoma of upper trachea with long-term survival after concurrent chemoradiotherapy

Prahlad H. Yathiraj, Sandeep Ail, Anshul Singh, Vidyasagar Mamidipudi

Research output: Contribution to journalArticle

Abstract

Upper tracheal malignancies are rare, and long-term survival is even rarer, especially among the unresectable malignancies. A 66-year-old chronic smoker was diagnosed as a locally advanced, non-metastatic squamous cell carcinoma of the upper trachea. Being unresectable, he was treated with six cycles of concurrent weekly cisplatin and three-dimensional conformal radiotherapy to a dose of 60 Gy in 30 fractions over 6 weeks. Follow-up imaging at 6 and 12 months revealed no disease. Our patient is presently 36 months post-treatment and is disease free without tracheal necrosis, fistula or radiation pneumonitis but developed hypothyroidism and is presently euthyroid. Concurrent chemoradiotherapy appears safe up to 3 years at least without any necrosis and is effective in controlling local disease. Meticulous planning obviates the need for higher technology like motion management techniques or intensity-modulated radiotherapy.

Original languageEnglish
Article numberbcr-2017-221284
JournalBMJ Case Reports
Volume2017
DOIs
Publication statusPublished - 01-01-2017

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Chemoradiotherapy
Trachea
Squamous Cell Carcinoma
Survival
Necrosis
Radiation Pneumonitis
Conformal Radiotherapy
Intensity-Modulated Radiotherapy
Hypothyroidism
Cisplatin
Fistula
Neoplasms
Technology
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Upper tracheal malignancies are rare, and long-term survival is even rarer, especially among the unresectable malignancies. A 66-year-old chronic smoker was diagnosed as a locally advanced, non-metastatic squamous cell carcinoma of the upper trachea. Being unresectable, he was treated with six cycles of concurrent weekly cisplatin and three-dimensional conformal radiotherapy to a dose of 60 Gy in 30 fractions over 6 weeks. Follow-up imaging at 6 and 12 months revealed no disease. Our patient is presently 36 months post-treatment and is disease free without tracheal necrosis, fistula or radiation pneumonitis but developed hypothyroidism and is presently euthyroid. Concurrent chemoradiotherapy appears safe up to 3 years at least without any necrosis and is effective in controlling local disease. Meticulous planning obviates the need for higher technology like motion management techniques or intensity-modulated radiotherapy.",
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Unresectable squamous cell carcinoma of upper trachea with long-term survival after concurrent chemoradiotherapy. / Yathiraj, Prahlad H.; Ail, Sandeep; Singh, Anshul; Mamidipudi, Vidyasagar.

In: BMJ Case Reports, Vol. 2017, bcr-2017-221284, 01.01.2017.

Research output: Contribution to journalArticle

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