Unusual lesions of the mediastinum

Fatima Shamsuddin, Urmila N. Khadilkar, Debarshi Saha

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: To study unusual lesions in the mediastinum, which do not originate from the thymus, lymph nodes, neural tissues or germ cells, and tissues that normally engender pathologic lesions in the mediastinum. Materials and Methods: Of the 65 cases seen, 12 unusual lesion were encountered in a 51/2 year period from 2006 to 2011. Results: Two cases of nodular colloid goiter and one each of the mediastinal cyst, undifferentiated carcinoma, and Langerhans cell histiocytosis (LCH) affected the anterosuperior mediastinum. In the middle mediastinum, one case each of the mesothelioma, malignant gastrointestinal stromal tumor (GIST), squamous cell carcinoma (SCC), solitary fibrous tumor (SFT), and pleomorphic sarcoma (PS) was seen. One case of meningeal melanocytoma (Mme) and primary pleural liposarcoma (PL) involved the posterior mediastinum. Persistent disease was seen in LCH after 2 years. Of all the cases with malignant lesions, only the patient with SCC was alive after 1 year. Conclusion: The cases of primary and SCC, LCH, melanocytoma, liposarcoma and PS, and GIST are unexpected and very rarely have paradigms in the mediastinum. Radiologic impression and knowledge of the compartment where these lesions arose from hardly assisted in arriving at a definitive opinion as the lesions were not typical of this location. A high index of suspicion and the immunohistochemical profile facilitated the final diagnosis.

Original languageEnglish
Pages (from-to)566-571
Number of pages6
JournalLung India
Volume32
Issue number6
DOIs
Publication statusPublished - 01-01-2015

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Mediastinum
Langerhans Cell Histiocytosis
Squamous Cell Carcinoma
Liposarcoma
Gastrointestinal Stromal Tumors
Sarcoma
Solitary Fibrous Tumors
Mediastinal Cyst
Nodular Goiter
Colloids
Germ Cells
Thymus Gland
Lymph Nodes
Carcinoma

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Shamsuddin, Fatima ; Khadilkar, Urmila N. ; Saha, Debarshi. / Unusual lesions of the mediastinum. In: Lung India. 2015 ; Vol. 32, No. 6. pp. 566-571.
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Unusual lesions of the mediastinum. / Shamsuddin, Fatima; Khadilkar, Urmila N.; Saha, Debarshi.

In: Lung India, Vol. 32, No. 6, 01.01.2015, p. 566-571.

Research output: Contribution to journalArticle

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