Use of molecular analogs for the bases in DNA

Stability of molecular pairs in gas phase and aqueous media and possible role of hydrogen bonding

C. Santhosh, P. C. Mishra

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In a recent experimental study, it was reported that replacement of thymine in the adenine-thymine base pair of DNA by its molecular analogs which cannot form proper hydrogen bonds with adenine (A) does not cause disruption of DNA structure and synthesis. AM1 and ab initio molecular orbital calculations and electric field mapping were carried out in order to examine the possibility of pairing of A with each one of two analogs of thymine in the gas phase. Self-consistent reaction field calculations were also carried out on the individual molecules and their pairs using the polarized continuum model in order to examine their stability in aqueous media. Our results are broadly in agreement with the conclusions drawn in the above-mentioned experimental work.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalInternational Journal of Quantum Chemistry
Volume68
Issue number5
DOIs
Publication statusPublished - 01-01-1998

Fingerprint

Thymine
thymine
Hydrogen bonds
deoxyribonucleic acid
Gases
adenines
Adenine
analogs
vapor phases
DNA
hydrogen
Orbital calculations
Molecular orbitals
molecular orbitals
Electric fields
hydrogen bonds
continuums
Molecules
electric fields
causes

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

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