Use of nonhuman primates in developing monoclonal antibodies

Sekhar M. Sonal, T. P. Aneesh, P. O. Shenoy

Research output: Contribution to journalArticle

Abstract

Nonhuman primates (NHP) are the preferred animal models for pre-clinical research because they approximate humans in physiology and genetics more closely than any other animal species. Vital advances in immunologic research have been made through the use of the NHP model, most notably in AIDS pathogenesis, treatment, and vaccine development. Cytokines and chemokines are soluble mediators of the immune system that play a crucial role in intercellular signaling, and in the recruitment of cells to inflammation sites. Identification of these molecules in NHP is important for the understanding of complex physiological and pathological mechanisms that occur in these species, and to demonstrate whether these mechanisms function similarly in humans. Recently, several antibodies specific for human cytokines that have the capacity to recognize homologous chemokines and cytokines of NHP origin have been identified. Currently, a panel of reagents is available which allows the simultaneous identification of cytokines and chemokines from Chimpanzees, Old World Monkeys, Rhesus Macaques, Baboons, Cynomolgus Macaques, Pig-tailed Macaques, and African Green Monkeys.

Original languageEnglish
Pages (from-to)20-21
Number of pages2
JournalPharma Times
Volume42
Issue number6
Publication statusPublished - 06-2010

Fingerprint

Primates
Monoclonal Antibodies
Chemokines
Cytokines
Macaca
Cercopithecidae
Cercopithecus aethiops
Pan troglodytes
Papio
Macaca mulatta
Research
Immune System
Acquired Immunodeficiency Syndrome
Swine
Vaccines
Animal Models
Inflammation
Antibodies

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Sonal, S. M., Aneesh, T. P., & Shenoy, P. O. (2010). Use of nonhuman primates in developing monoclonal antibodies. Pharma Times, 42(6), 20-21.
Sonal, Sekhar M. ; Aneesh, T. P. ; Shenoy, P. O. / Use of nonhuman primates in developing monoclonal antibodies. In: Pharma Times. 2010 ; Vol. 42, No. 6. pp. 20-21.
@article{186eb61698074d59b0265d2d44fdaab4,
title = "Use of nonhuman primates in developing monoclonal antibodies",
abstract = "Nonhuman primates (NHP) are the preferred animal models for pre-clinical research because they approximate humans in physiology and genetics more closely than any other animal species. Vital advances in immunologic research have been made through the use of the NHP model, most notably in AIDS pathogenesis, treatment, and vaccine development. Cytokines and chemokines are soluble mediators of the immune system that play a crucial role in intercellular signaling, and in the recruitment of cells to inflammation sites. Identification of these molecules in NHP is important for the understanding of complex physiological and pathological mechanisms that occur in these species, and to demonstrate whether these mechanisms function similarly in humans. Recently, several antibodies specific for human cytokines that have the capacity to recognize homologous chemokines and cytokines of NHP origin have been identified. Currently, a panel of reagents is available which allows the simultaneous identification of cytokines and chemokines from Chimpanzees, Old World Monkeys, Rhesus Macaques, Baboons, Cynomolgus Macaques, Pig-tailed Macaques, and African Green Monkeys.",
author = "Sonal, {Sekhar M.} and Aneesh, {T. P.} and Shenoy, {P. O.}",
year = "2010",
month = "6",
language = "English",
volume = "42",
pages = "20--21",
journal = "Pharma Times",
issn = "0031-6849",
publisher = "Indian Pharmaceutical Association",
number = "6",

}

Sonal, SM, Aneesh, TP & Shenoy, PO 2010, 'Use of nonhuman primates in developing monoclonal antibodies', Pharma Times, vol. 42, no. 6, pp. 20-21.

Use of nonhuman primates in developing monoclonal antibodies. / Sonal, Sekhar M.; Aneesh, T. P.; Shenoy, P. O.

In: Pharma Times, Vol. 42, No. 6, 06.2010, p. 20-21.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Use of nonhuman primates in developing monoclonal antibodies

AU - Sonal, Sekhar M.

AU - Aneesh, T. P.

AU - Shenoy, P. O.

PY - 2010/6

Y1 - 2010/6

N2 - Nonhuman primates (NHP) are the preferred animal models for pre-clinical research because they approximate humans in physiology and genetics more closely than any other animal species. Vital advances in immunologic research have been made through the use of the NHP model, most notably in AIDS pathogenesis, treatment, and vaccine development. Cytokines and chemokines are soluble mediators of the immune system that play a crucial role in intercellular signaling, and in the recruitment of cells to inflammation sites. Identification of these molecules in NHP is important for the understanding of complex physiological and pathological mechanisms that occur in these species, and to demonstrate whether these mechanisms function similarly in humans. Recently, several antibodies specific for human cytokines that have the capacity to recognize homologous chemokines and cytokines of NHP origin have been identified. Currently, a panel of reagents is available which allows the simultaneous identification of cytokines and chemokines from Chimpanzees, Old World Monkeys, Rhesus Macaques, Baboons, Cynomolgus Macaques, Pig-tailed Macaques, and African Green Monkeys.

AB - Nonhuman primates (NHP) are the preferred animal models for pre-clinical research because they approximate humans in physiology and genetics more closely than any other animal species. Vital advances in immunologic research have been made through the use of the NHP model, most notably in AIDS pathogenesis, treatment, and vaccine development. Cytokines and chemokines are soluble mediators of the immune system that play a crucial role in intercellular signaling, and in the recruitment of cells to inflammation sites. Identification of these molecules in NHP is important for the understanding of complex physiological and pathological mechanisms that occur in these species, and to demonstrate whether these mechanisms function similarly in humans. Recently, several antibodies specific for human cytokines that have the capacity to recognize homologous chemokines and cytokines of NHP origin have been identified. Currently, a panel of reagents is available which allows the simultaneous identification of cytokines and chemokines from Chimpanzees, Old World Monkeys, Rhesus Macaques, Baboons, Cynomolgus Macaques, Pig-tailed Macaques, and African Green Monkeys.

UR - http://www.scopus.com/inward/record.url?scp=77954463638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954463638&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:77954463638

VL - 42

SP - 20

EP - 21

JO - Pharma Times

JF - Pharma Times

SN - 0031-6849

IS - 6

ER -