Usefulness of salivary alpha amylase as a biomarker of chronic stress and stress related oral mucosal changes - a pilot study

Ravindranath Vineetha, Keerthilatha M. Pai, Manoj Vengal, Kodyalamoole Gopalakrishna, Dinesh Narayanakurup

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Introduction: Salivary biomarkers are suggested to provide a reliable, noninvasive and objective measurement of chronic psychosocial stress and helps in assessment of pivotal role of stress in causation or precipitation of multitude of health problems Objectives: To evaluate the usefulness of salivary alpha amylase activity as an objective indicator of chronic stress and to find out any correlation between stress- related mucosal complaints and its levels. Study Design: Study was conducted among 50 subjects suffering from chronic stress related problems and 50 non-stressed individuals who were screened with a psychometric questionnaire. Brief case history and oral examination was carried out and about one ml of unstimulated saliva was collected. Salivary alpha amylase levels estimated were compared between study and control group and between subjects with and without oral mucosal changes using non parametric Mann Whitney U test Results: There was statistically significant higher salivary alpha amylase levels in study group (p = .002) and salivary alpha amylase between the oral mucosal complaints group and without oral mucosal complaints group within the total study population were found to be statistically significant (p=0.045). Conclusion: Salivary amylase activity increases in patients with chronic psychosocial stress and may be used as a biomarker of chronic stress, but it may not be an indicator to suggest the development of stress related oral mucosal changes.

Original languageEnglish
JournalJournal of Clinical and Experimental Dentistry
Volume6
Issue number2
DOIs
Publication statusPublished - 01-01-2014

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Salivary alpha-Amylases
Biomarkers
Oral Diagnosis
Amylases
Nonparametric Statistics
Saliva
Psychometrics
Causality
Control Groups
Health
Population

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

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abstract = "Introduction: Salivary biomarkers are suggested to provide a reliable, noninvasive and objective measurement of chronic psychosocial stress and helps in assessment of pivotal role of stress in causation or precipitation of multitude of health problems Objectives: To evaluate the usefulness of salivary alpha amylase activity as an objective indicator of chronic stress and to find out any correlation between stress- related mucosal complaints and its levels. Study Design: Study was conducted among 50 subjects suffering from chronic stress related problems and 50 non-stressed individuals who were screened with a psychometric questionnaire. Brief case history and oral examination was carried out and about one ml of unstimulated saliva was collected. Salivary alpha amylase levels estimated were compared between study and control group and between subjects with and without oral mucosal changes using non parametric Mann Whitney U test Results: There was statistically significant higher salivary alpha amylase levels in study group (p = .002) and salivary alpha amylase between the oral mucosal complaints group and without oral mucosal complaints group within the total study population were found to be statistically significant (p=0.045). Conclusion: Salivary amylase activity increases in patients with chronic psychosocial stress and may be used as a biomarker of chronic stress, but it may not be an indicator to suggest the development of stress related oral mucosal changes.",
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Usefulness of salivary alpha amylase as a biomarker of chronic stress and stress related oral mucosal changes - a pilot study. / Vineetha, Ravindranath; Pai, Keerthilatha M.; Vengal, Manoj; Gopalakrishna, Kodyalamoole; Narayanakurup, Dinesh.

In: Journal of Clinical and Experimental Dentistry, Vol. 6, No. 2, 01.01.2014.

Research output: Contribution to journalArticle

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