Vagaries of alcoholism and its clinical significance

B. K. Manjunatha Goud, O. Sarsina Devi, Bhavna Nayal, C. V. Raghuveer, Niveditha Suvarna, R. N. Devaki

Research output: Contribution to journalReview article

Abstract

In most countries chronic alcohol consumption is a medical problem of great magnitude with important socio- economic ramifications. Liver cirrhosis is one of the first causes of death among middle-aged subjects, especially males, and, in several populations studied, the evolution of the rate of mortality by cirrhosis is parallel to the amount of alcohol intake. Alcohol's adverse effects on the blood building, or hematopoietic, system are both direct and indirect. The direct consequences of excessive alcohol consumption include toxic effects on the bone marrow, the blood cell precursors and the mature red blood cells (RBC's), white blood cells (WBC's) and platelets. Alcohol's indirect effects include nutritional deficiencies that impair the production and function of various blood cells. The present review analyses the genetic factors altering the hepatic metabolism of alcohol, the metabolic changes produced in the liver during alcohol metabolism and their relationship with the pathogenesis of the disease,hematological changes, pharmacological interactions and various diseases associated with excessive alcohol consumption.

Original languageEnglish
Pages (from-to)66-69
Number of pages4
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume8
Issue number1
Publication statusPublished - 01-05-2011

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Alcoholism
Alcohols
Alcohol Drinking
Blood Cells
Hematopoietic System
Hematologic Diseases
Poisons
Liver
Malnutrition
Bone Marrow Cells
Liver Cirrhosis
Statistical Factor Analysis
Cause of Death
Leukocytes
Fibrosis
Blood Platelets
Erythrocytes
Economics
Pharmacology
Mortality

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Manjunatha Goud, B. K., Sarsina Devi, O., Nayal, B., Raghuveer, C. V., Suvarna, N., & Devaki, R. N. (2011). Vagaries of alcoholism and its clinical significance. International Journal of Pharmaceutical Sciences Review and Research, 8(1), 66-69.
Manjunatha Goud, B. K. ; Sarsina Devi, O. ; Nayal, Bhavna ; Raghuveer, C. V. ; Suvarna, Niveditha ; Devaki, R. N. / Vagaries of alcoholism and its clinical significance. In: International Journal of Pharmaceutical Sciences Review and Research. 2011 ; Vol. 8, No. 1. pp. 66-69.
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Manjunatha Goud, BK, Sarsina Devi, O, Nayal, B, Raghuveer, CV, Suvarna, N & Devaki, RN 2011, 'Vagaries of alcoholism and its clinical significance', International Journal of Pharmaceutical Sciences Review and Research, vol. 8, no. 1, pp. 66-69.

Vagaries of alcoholism and its clinical significance. / Manjunatha Goud, B. K.; Sarsina Devi, O.; Nayal, Bhavna; Raghuveer, C. V.; Suvarna, Niveditha; Devaki, R. N.

In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 8, No. 1, 01.05.2011, p. 66-69.

Research output: Contribution to journalReview article

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Manjunatha Goud BK, Sarsina Devi O, Nayal B, Raghuveer CV, Suvarna N, Devaki RN. Vagaries of alcoholism and its clinical significance. International Journal of Pharmaceutical Sciences Review and Research. 2011 May 1;8(1):66-69.