Vagaries of alcoholism and its clinical significance

B. K. Manjunatha Goud, O. Sarsina Devi, Bhavna Nayal, C. V. Raghuveer, Niveditha Suvarna, R. N. Devaki

Research output: Contribution to journalReview articlepeer-review

Abstract

In most countries chronic alcohol consumption is a medical problem of great magnitude with important socio- economic ramifications. Liver cirrhosis is one of the first causes of death among middle-aged subjects, especially males, and, in several populations studied, the evolution of the rate of mortality by cirrhosis is parallel to the amount of alcohol intake. Alcohol's adverse effects on the blood building, or hematopoietic, system are both direct and indirect. The direct consequences of excessive alcohol consumption include toxic effects on the bone marrow, the blood cell precursors and the mature red blood cells (RBC's), white blood cells (WBC's) and platelets. Alcohol's indirect effects include nutritional deficiencies that impair the production and function of various blood cells. The present review analyses the genetic factors altering the hepatic metabolism of alcohol, the metabolic changes produced in the liver during alcohol metabolism and their relationship with the pathogenesis of the disease,hematological changes, pharmacological interactions and various diseases associated with excessive alcohol consumption.

Original languageEnglish
Pages (from-to)66-69
Number of pages4
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume8
Issue number1
Publication statusPublished - 01-05-2011

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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