Validated UV spectrophotometric method development and stability studies of Acamprosate calcium in bulk and tablet dosage form

A. Kirankumar, B. Mamatha, M. Sasikala, S. Monika, D. Ranganayakulu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A simple, rapid, accurate, precise, specific and economical spectrophotometric method for estimation of Acamprosate calcium in tablet dosage form has been developed. Beer-Lambert's law was followed in the concentration range of 10-50μg/ml (r2= 0. 999). LOD and LOQ were found to be 0. 3626μg/ml & 1. 0989μg/ml respectively. The result of percentage recoveryand placebo interference shows that the method was not affected by the presence of common excipients. Thepercentage assay ofAcamprosate calcium in tabletswas 99. 4%w/w. The method was validated by determining its sensitivity, accuracyand precision which proved suitability of the developed method for the routine estimation of Acamprosate calciumin solid dosage form and it was subjected to stress degradation under different conditions recommended by ICH.

Original languageEnglish
Pages (from-to)1241-1246
Number of pages6
JournalInternational Journal of PharmTech Research
Volume5
Issue number3
Publication statusPublished - 01-07-2013

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Dosage Forms
Tablets
Excipients
Placebos
Calcium
acamprosate

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

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abstract = "A simple, rapid, accurate, precise, specific and economical spectrophotometric method for estimation of Acamprosate calcium in tablet dosage form has been developed. Beer-Lambert's law was followed in the concentration range of 10-50μg/ml (r2= 0. 999). LOD and LOQ were found to be 0. 3626μg/ml & 1. 0989μg/ml respectively. The result of percentage recoveryand placebo interference shows that the method was not affected by the presence of common excipients. Thepercentage assay ofAcamprosate calcium in tabletswas 99. 4{\%}w/w. The method was validated by determining its sensitivity, accuracyand precision which proved suitability of the developed method for the routine estimation of Acamprosate calciumin solid dosage form and it was subjected to stress degradation under different conditions recommended by ICH.",
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Validated UV spectrophotometric method development and stability studies of Acamprosate calcium in bulk and tablet dosage form. / Kirankumar, A.; Mamatha, B.; Sasikala, M.; Monika, S.; Ranganayakulu, D.

In: International Journal of PharmTech Research, Vol. 5, No. 3, 01.07.2013, p. 1241-1246.

Research output: Contribution to journalArticle

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T1 - Validated UV spectrophotometric method development and stability studies of Acamprosate calcium in bulk and tablet dosage form

AU - Kirankumar, A.

AU - Mamatha, B.

AU - Sasikala, M.

AU - Monika, S.

AU - Ranganayakulu, D.

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