Vancomycin intermediate and vancomycin resistant staphylococcus aureus - mechanisms, clinical significance, and detection

Research output: Contribution to journalReview article

Abstract

Vancomycin is used as the antibiotic of choice for severe infection caused by methicillin-resistant Staphylococcus aureus. Increased use of vancomycin and the selective pressure has resulted in the emergence of S. aureus with reduced susceptibility to vancomycin and vancomycin-resistant S. aureus. This review summarizes the definition, mechanism, clinical significance, and epidemiology of S. aureus with reduced susceptibility to vancomycin. It also discusses laboratory methods for detection and treatment options available for these pathogens.

Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume10
Issue number6
DOIs
Publication statusPublished - 2017

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Vancomycin
Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
Epidemiology
Anti-Bacterial Agents
Infection

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

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title = "Vancomycin intermediate and vancomycin resistant staphylococcus aureus - mechanisms, clinical significance, and detection",
abstract = "Vancomycin is used as the antibiotic of choice for severe infection caused by methicillin-resistant Staphylococcus aureus. Increased use of vancomycin and the selective pressure has resulted in the emergence of S. aureus with reduced susceptibility to vancomycin and vancomycin-resistant S. aureus. This review summarizes the definition, mechanism, clinical significance, and epidemiology of S. aureus with reduced susceptibility to vancomycin. It also discusses laboratory methods for detection and treatment options available for these pathogens.",
author = "Jyoti Kumari and Shenoy, {Shalini M.} and Ashwini Hegde and K. Vidyalakshmi and M. Chakrapani and Bhat, {Gopalkrishna K.}",
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AU - Kumari, Jyoti

AU - Shenoy, Shalini M.

AU - Hegde, Ashwini

AU - Vidyalakshmi, K.

AU - Chakrapani, M.

AU - Bhat, Gopalkrishna K.

PY - 2017

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AB - Vancomycin is used as the antibiotic of choice for severe infection caused by methicillin-resistant Staphylococcus aureus. Increased use of vancomycin and the selective pressure has resulted in the emergence of S. aureus with reduced susceptibility to vancomycin and vancomycin-resistant S. aureus. This review summarizes the definition, mechanism, clinical significance, and epidemiology of S. aureus with reduced susceptibility to vancomycin. It also discusses laboratory methods for detection and treatment options available for these pathogens.

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