5 Citations (Scopus)

Abstract

Emergence of multi and pan-drug resistant Gram-negative bacteria causing nosocomial infections in intensive care settings has become a challenge for clinicians. The mortality rate of ventilator-associated pneumonia (VAP) is known to increase when the initial microbiological diagnosis and antimicrobial therapy are inappropriate. We present a case of a 18-year-old man, who after being admitted following an accident, had developed VAP due to multidrug resistant Pseudomonas aeruginosa and Acinetobacter spp. and had a downhill clinical course despite broadspectrum antibiotic treatment. The strains were found to be Col-S, as the susceptibility was tested. Colistin was instituted, with remarkable recovery. It is imperative to diagnose VAP with multi-drug resistant strains as early as possible; colistin, the 'last resort' antibiotic, if instituted with proper monitoring at the right time, can be life saving.

Original languageEnglish
Pages (from-to)444-446
Number of pages3
JournalBrazilian Journal of Infectious Diseases
Volume12
Issue number5
Publication statusPublished - 2008

Fingerprint

Colistin
Ventilator-Associated Pneumonia
Anti-Bacterial Agents
Acinetobacter
Critical Care
Cross Infection
Gram-Negative Bacteria
Pharmaceutical Preparations
Pseudomonas aeruginosa
Accidents
Mortality
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "Ventilator-associated pneumonia with Col-S strains: A successful comeback of colistin!",
abstract = "Emergence of multi and pan-drug resistant Gram-negative bacteria causing nosocomial infections in intensive care settings has become a challenge for clinicians. The mortality rate of ventilator-associated pneumonia (VAP) is known to increase when the initial microbiological diagnosis and antimicrobial therapy are inappropriate. We present a case of a 18-year-old man, who after being admitted following an accident, had developed VAP due to multidrug resistant Pseudomonas aeruginosa and Acinetobacter spp. and had a downhill clinical course despite broadspectrum antibiotic treatment. The strains were found to be Col-S, as the susceptibility was tested. Colistin was instituted, with remarkable recovery. It is imperative to diagnose VAP with multi-drug resistant strains as early as possible; colistin, the 'last resort' antibiotic, if instituted with proper monitoring at the right time, can be life saving.",
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T1 - Ventilator-associated pneumonia with Col-S strains

T2 - A successful comeback of colistin!

AU - Mukhopadhyay, Chiranjay

AU - Krishna, S.

AU - Vandana, K. E.

AU - Shenoy, A.

AU - Bairy, I.

PY - 2008

Y1 - 2008

N2 - Emergence of multi and pan-drug resistant Gram-negative bacteria causing nosocomial infections in intensive care settings has become a challenge for clinicians. The mortality rate of ventilator-associated pneumonia (VAP) is known to increase when the initial microbiological diagnosis and antimicrobial therapy are inappropriate. We present a case of a 18-year-old man, who after being admitted following an accident, had developed VAP due to multidrug resistant Pseudomonas aeruginosa and Acinetobacter spp. and had a downhill clinical course despite broadspectrum antibiotic treatment. The strains were found to be Col-S, as the susceptibility was tested. Colistin was instituted, with remarkable recovery. It is imperative to diagnose VAP with multi-drug resistant strains as early as possible; colistin, the 'last resort' antibiotic, if instituted with proper monitoring at the right time, can be life saving.

AB - Emergence of multi and pan-drug resistant Gram-negative bacteria causing nosocomial infections in intensive care settings has become a challenge for clinicians. The mortality rate of ventilator-associated pneumonia (VAP) is known to increase when the initial microbiological diagnosis and antimicrobial therapy are inappropriate. We present a case of a 18-year-old man, who after being admitted following an accident, had developed VAP due to multidrug resistant Pseudomonas aeruginosa and Acinetobacter spp. and had a downhill clinical course despite broadspectrum antibiotic treatment. The strains were found to be Col-S, as the susceptibility was tested. Colistin was instituted, with remarkable recovery. It is imperative to diagnose VAP with multi-drug resistant strains as early as possible; colistin, the 'last resort' antibiotic, if instituted with proper monitoring at the right time, can be life saving.

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